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university OF MISSOURI
RECEIVED
COLUMBIA
SEP 27 1928
DEPARTMENT OF CHEMISTRY
September 23, 1928
Mr. H. H. Barker
United States Radium Corporation
535 Pearl Street
New York City
My dear Howard:
Your letter and check covering balance of expense account
have just come to hand. I shall deposit check on Monday. This additionto
my bank balance may help to keep my standing with the bank at par. A minimum
cash balance of $100.00 is now required by our local banks.
Being interested in the quantitative aspect of our radium
problem, I am pleased to get your data on the radium content of excreta in the
Dunn case. Let us examine these data and make a few computations with a view
of getting some idea as to the probable sensitiveness of this method for de-
tecting radium in living persons. Altho the average of the figures gives a
total daily elimination of radium by Miss Dunn of more than 0.010 micrograms,
let us take 0.010 micrograms (10 x 10-9 g) in our computations for just at
present we are merely concerned with the order of magnitude and not exact fi-
gures. If we assume that the dry weight of the entire sample excreta had been
used in making the radium determinations--and a 5 gram sample can be handled
without introducing experimental difficulties-- it is seen that the emanation
from it will produce a drift of the leaf of a Lind electroscope of about 1
div. per sec. since the constant of the instrument lies very close to 10 X 10-9
grams radium per div. per sec. Since the radium content of Miss Dunn turned
out to be about 100 micrograms, it follows that per microgram of radium the
radium in dai ly excreta would produce a drift of about 0.01 div. per sec. an
amount well within the range of detection by the emanation method. On this
basis, the daily excreta from a subject containing about 5 micrograms should
contain sufficient radium to produce a net drift of about 0.05 div. per sec.-
a value fully 20 times the drift observed for a 5 microgram subject when the
tests are made by the gamma ray instrument or with the Lind electroscope on
expired air. I realize full well that one must not generalize from data
based on a single case. One must also expect wide differences in the quanti-
ties of radium eliminated by different subjects or the same subject at differ-
ent times; nevertheless, this computation seems to indicate that the determi-
nationo of radium in excreta by the emanation method may turn out to be fully
as delicate and positive as any of the other methods on which we have worked
so faithfully. Is not our objective to find ways and means of detecting
radium in living persons? It is largely on this basis that I proposed that
we proceed to make at least a few random determinations of radium with you as
subject.
university OF MISSOURI
COLUMBIA
department OF CHEMISTRY
-2-
H.H. Barker
The introduction to the forthcoming report is enclosed and I
am sending a copy to Dr. Flinn. Please read it critically, make additions
and revisions as you think best. I feel that the introduction to your
problem must be stated in simple terms but must also be accurate and that it
must have in it the element of appeal to the reader.
To save time I shall send a copy of this note to Dr. Flinn.
Sincerely yours,
Herman Schlundt
HS
c
b
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"ocrText": "university OF MISSOURI\nRECEIVED\nCOLUMBIA\nSEP 27 1928\nDEPARTMENT OF CHEMISTRY\nSeptember 23, 1928\nMr. H. H. Barker\nUnited States Radium Corporation\n535 Pearl Street\nNew York City\nMy dear Howard:\nYour letter and check covering balance of expense account\nhave just come to hand. I shall deposit check on Monday. This additionto\nmy bank balance may help to keep my standing with the bank at par. A minimum\ncash balance of $100.00 is now required by our local banks.\nBeing interested in the quantitative aspect of our radium\nproblem, I am pleased to get your data on the radium content of excreta in the\nDunn case. Let us examine these data and make a few computations with a view\nof getting some idea as to the probable sensitiveness of this method for de-\ntecting radium in living persons. Altho the average of the figures gives a\ntotal daily elimination of radium by Miss Dunn of more than 0.010 micrograms,\nlet us take 0.010 micrograms (10 x 10-9 g) in our computations for just at\npresent we are merely concerned with the order of magnitude and not exact fi-\ngures. If we assume that the dry weight of the entire sample excreta had been\nused in making the radium determinations--and a 5 gram sample can be handled\nwithout introducing experimental difficulties-- it is seen that the emanation\nfrom it will produce a drift of the leaf of a Lind electroscope of about 1\ndiv. per sec. since the constant of the instrument lies very close to 10 X 10-9\ngrams radium per div. per sec. Since the radium content of Miss Dunn turned\nout to be about 100 micrograms, it follows that per microgram of radium the\nradium in dai ly excreta would produce a drift of about 0.01 div. per sec. an\namount well within the range of detection by the emanation method. On this\nbasis, the daily excreta from a subject containing about 5 micrograms should\ncontain sufficient radium to produce a net drift of about 0.05 div. per sec.-\na value fully 20 times the drift observed for a 5 microgram subject when the\ntests are made by the gamma ray instrument or with the Lind electroscope on\nexpired air. I realize full well that one must not generalize from data\nbased on a single case. One must also expect wide differences in the quanti-\nties of radium eliminated by different subjects or the same subject at differ-\nent times; nevertheless, this computation seems to indicate that the determi-\nnationo of radium in excreta by the emanation method may turn out to be fully\nas delicate and positive as any of the other methods on which we have worked\nso faithfully. Is not our objective to find ways and means of detecting\nradium in living persons? It is largely on this basis that I proposed that\nwe proceed to make at least a few random determinations of radium with you as\nsubject.\nuniversity OF MISSOURI\nCOLUMBIA\ndepartment OF CHEMISTRY\n-2-\nH.H. Barker\nThe introduction to the forthcoming report is enclosed and I\nam sending a copy to Dr. Flinn. Please read it critically, make additions\nand revisions as you think best. I feel that the introduction to your\nproblem must be stated in simple terms but must also be accurate and that it\nmust have in it the element of appeal to the reader.\nTo save time I shall send a copy of this note to Dr. Flinn.\nSincerely yours,\nHerman Schlundt\nHS\nc\nb"
}