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MAY 11:24 FR CDC/OSH-OD 97704885767 TO 912022058313 P.03/08 MAY-04-88 10:10 From:CHAMBLEE IC 7704887422 T-704 P.03/08 Job-200 JOEM Volume 40, Number 3, March 1998 271 for ETS exposure.⁷⁻⁹ One potential Biologic monitoring of exposure area has an area of 8679 ft.² Gaming drawback of vapor-phase nicotine is to ETS is most commonly conducted activities are in operation 24 hours that the physical properties of vapor- by measuring cotinine in the serum per day, seven days a week. The phase nicotine on indoor surfaces and/or urine of potentially-exposed maximum occupancy of the casino is can alter (increase or decrease) its persons. 3.8.14-16 Cotinine. which is 9560 persons. The casino employs concentration relative to other ETS the major metabolite of nicotine, has approximately 800 persons who components. Respirable particulate a half-life of approximately 16-20 work on the casino floor, approxi- has also been used as a marker of hours, reflecting exposure to nicotine mately 330 are full-time dealers and ETS, but it may be difficult to sepa- from the previous one to two days.³ approximately 180 are full-time rate the ETS-associated particulate There are no NIOSH, ACGIH, or dealer supervisors. Specific game or from that of other indoor sources. 7-0 OSHA criteria for cotinine in blood area assignments for dealers and su- The concentrations of these markers or urine. Although studies reporting pervisors were made at the start of in ETS are consistently lower than counine levels in non-smokers ex- each shift and changed daily (and their respective occupational air- posed to ETS have been summa- sometimes within a given work borne exposure criteria. which were rized,¹² differences in laboratory shift). Other casino floor employees based primarily on acute effects. The methods sometimes make it difficult include waitresses. cashiers. and se- NIOSH Recommended Exposure to compare cotinine levels deter- curity personnel. Limit (REL) and the American Con- mined in different laboratories. A The heating. ventilating, and air- ference of Governmental Industrial study of more than 600 non-smokers conditioning system was controlled Hygienists' (ACGIH) threshold limit attending a medical clinic found a by a Honeywell building manage- value (TLV) for nicotine, used pri- mean urine cotinine level of 8.8 ment system (Honeywell Inc., Min- marily for exposure assessments in ng/mL (range, 0-85). with increased neapolis. MN). There were 17 air agriculture, are 500 micrograms per levels correlating with reported ex- handling units, each rated to supply cubic meter of air (µg/m³). and are posures.¹⁴ Another study found a 47,000 cubic feel per minute of con- not applicable in evaluations of ETS mean urine cotinine level of 9.2 ditioned air. Assuming a maximum exposure. 10.11 A model used to de- ng/mL among non-smokers exposed casino capacity (9560 persons) and a rive a health-based standard for ETS to ETS at home or work. 18 A recent reported minimum 30% outdoor air has shown that an eight-hour, time US population survey measuring se- intake, an outside air rate of 25 cubic weighted average exposure to 2.3 rum cotinine in over 2600 working feet per minute per person (cfm/ µg/m³ of nicotine would correspond adults reported the following geo- person) can be calculated. Although to 3 lung cancer deaths among metric means by category: (1) no the ventilation system was not in- 10,000 exposed over a working life- reported ETS exposure: 0.132 ng/ spected, carbon dioxide (CO₂) mea- time.¹² The US Department of La- mL; (2) reported ETS exposure at surements (which ranged from 425 bor. Occupational Safety and Health work: 0.318 ng/mL; (3) reported to 850 parts per million) were con- Administration (OSHA) general in- ETS exposure at home: 0.651 ng/ sistent with the calculated outdoor dustry permissible exposure 11mit mL: and (4) reported ETS exposure air supply rates. (PEL) for respirable particulate not at home and work: 0.926 ng/mL. Tobacco smoking by customers is composed of a substance that has its Although some foods. including permitted throughout the casino own PEL is 5000 µg/m³ (the ACGIH tea, tomatoes, poratoes, and cauli- floor; employees do not smoke while TLV is 3000 µg/m:³ there is no flower. may contain nicotine in mea- on duty. Although some gaming ta- REL). 11.13 In contrast, the mean area surable quantities and therefore have bles are designated as non-smoking, air nicotine concentrations reported been suggested as a source of cotin- the non-smoking tables are generally in ETS studies of public buildings ine in the body.¹⁹ the amount of located adjacent to tables where have ranged from 0.7-37 µg/m³, cotinine in serum as a result of food smoking is permitted. The employee concentrations in restaurants and intake has been shown to be ex- cafeteria has smoking and non- bars have ranged from 2.3-65.5 Hg/ tremely low relative to that resulting smoking areas, bur these areas are m³, and concentrations in gaming from ETS exposure. not physically partitioned. and to- parlors and betting shops have bacco smoke is evident in the non- ranged from 11-19 µg/m.¹.⁷.¹² One Workplace Description smoking area. Employee lounges are study found that the median air nic- The casino that was evaluated was designated non-smoking areas. otine concentration was 8.6 µg/m³ in constructed in 1979 and offers a offices at worksites that allowed variety of gaming activities, includ- Methods smoking.⁶ Respirable particulate ing slot machines. roulette, black- The field study was performed in measurements have ranged up to 115 jack. baccarat. craps. and poker. The March 1996 and consisted of envi- µg/m³ in office buildings and up to gaming floor has an area of 71.380 ronmental and medical evaluations. 843 µg/m³ in restaurants.⁷ square feet (ft²): a separate poker Employee representatives and man-

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    "ocrText": "MAY 11:24 FR CDC/OSH-OD\n97704885767 TO 912022058313\nP.03/08\nMAY-04-88 10:10 From:CHAMBLEE IC\n7704887422\nT-704 P.03/08 Job-200\nJOEM Volume 40, Number 3, March 1998\n271\nfor ETS exposure.⁷⁻⁹ One potential\nBiologic monitoring of exposure\narea has an area of 8679 ft.² Gaming\ndrawback of vapor-phase nicotine is\nto ETS is most commonly conducted\nactivities are in operation 24 hours\nthat the physical properties of vapor-\nby measuring cotinine in the serum\nper day, seven days a week. The\nphase nicotine on indoor surfaces\nand/or urine of potentially-exposed\nmaximum occupancy of the casino is\ncan alter (increase or decrease) its\npersons. 3.8.14-16 Cotinine. which is\n9560 persons. The casino employs\nconcentration relative to other ETS\nthe major metabolite of nicotine, has\napproximately 800 persons who\ncomponents. Respirable particulate\na half-life of approximately 16-20\nwork on the casino floor, approxi-\nhas also been used as a marker of\nhours, reflecting exposure to nicotine\nmately 330 are full-time dealers and\nETS, but it may be difficult to sepa-\nfrom the previous one to two days.³\napproximately 180 are full-time\nrate the ETS-associated particulate\nThere are no NIOSH, ACGIH, or\ndealer supervisors. Specific game or\nfrom that of other indoor sources. 7-0\nOSHA criteria for cotinine in blood\narea assignments for dealers and su-\nThe concentrations of these markers\nor urine. Although studies reporting\npervisors were made at the start of\nin ETS are consistently lower than\ncounine levels in non-smokers ex-\neach shift and changed daily (and\ntheir respective occupational air-\nposed to ETS have been summa-\nsometimes within a given work\nborne exposure criteria. which were\nrized,¹² differences in laboratory\nshift). Other casino floor employees\nbased primarily on acute effects. The\nmethods sometimes make it difficult\ninclude waitresses. cashiers. and se-\nNIOSH Recommended Exposure\nto compare cotinine levels deter-\ncurity personnel.\nLimit (REL) and the American Con-\nmined in different laboratories. A\nThe heating. ventilating, and air-\nference of Governmental Industrial\nstudy of more than 600 non-smokers\nconditioning system was controlled\nHygienists' (ACGIH) threshold limit\nattending a medical clinic found a\nby a Honeywell building manage-\nvalue (TLV) for nicotine, used pri-\nmean urine cotinine level of 8.8\nment system (Honeywell Inc., Min-\nmarily for exposure assessments in\nng/mL (range, 0-85). with increased\nneapolis. MN). There were 17 air\nagriculture, are 500 micrograms per\nlevels correlating with reported ex-\nhandling units, each rated to supply\ncubic meter of air (µg/m³). and are\nposures.¹⁴ Another study found a\n47,000 cubic feel per minute of con-\nnot applicable in evaluations of ETS\nmean urine cotinine level of 9.2\nditioned air. Assuming a maximum\nexposure. 10.11 A model used to de-\nng/mL among non-smokers exposed\ncasino capacity (9560 persons) and a\nrive a health-based standard for ETS\nto ETS at home or work. 18 A recent\nreported minimum 30% outdoor air\nhas shown that an eight-hour, time\nUS population survey measuring se-\nintake, an outside air rate of 25 cubic\nweighted average exposure to 2.3\nrum cotinine in over 2600 working\nfeet per minute per person (cfm/\nµg/m³ of nicotine would correspond\nadults reported the following geo-\nperson) can be calculated. Although\nto 3 lung cancer deaths among\nmetric means by category: (1) no\nthe ventilation system was not in-\n10,000 exposed over a working life-\nreported ETS exposure: 0.132 ng/\nspected, carbon dioxide (CO₂) mea-\ntime.¹² The US Department of La-\nmL; (2) reported ETS exposure at\nsurements (which ranged from 425\nbor. Occupational Safety and Health\nwork: 0.318 ng/mL; (3) reported\nto 850 parts per million) were con-\nAdministration (OSHA) general in-\nETS exposure at home: 0.651 ng/\nsistent with the calculated outdoor\ndustry permissible exposure 11mit\nmL: and (4) reported ETS exposure\nair supply rates.\n(PEL) for respirable particulate not\nat home and work: 0.926 ng/mL.\nTobacco smoking by customers is\ncomposed of a substance that has its\nAlthough some foods. including\npermitted throughout the casino\nown PEL is 5000 µg/m³ (the ACGIH\ntea, tomatoes, poratoes, and cauli-\nfloor; employees do not smoke while\nTLV is 3000 µg/m:³ there is no\nflower. may contain nicotine in mea-\non duty. Although some gaming ta-\nREL). 11.13 In contrast, the mean area\nsurable quantities and therefore have\nbles are designated as non-smoking,\nair nicotine concentrations reported\nbeen suggested as a source of cotin-\nthe non-smoking tables are generally\nin ETS studies of public buildings\nine in the body.¹⁹ the amount of\nlocated adjacent to tables where\nhave ranged from 0.7-37 µg/m³,\ncotinine in serum as a result of food\nsmoking is permitted. The employee\nconcentrations in restaurants and\nintake has been shown to be ex-\ncafeteria has smoking and non-\nbars have ranged from 2.3-65.5 Hg/\ntremely low relative to that resulting\nsmoking areas, bur these areas are\nm³, and concentrations in gaming\nfrom ETS exposure.\nnot physically partitioned. and to-\nparlors and betting shops have\nbacco smoke is evident in the non-\nranged from 11-19 µg/m.¹.⁷.¹² One\nWorkplace Description\nsmoking area. Employee lounges are\nstudy found that the median air nic-\nThe casino that was evaluated was\ndesignated non-smoking areas.\notine concentration was 8.6 µg/m³ in\nconstructed in 1979 and offers a\noffices at worksites that allowed\nvariety of gaming activities, includ-\nMethods\nsmoking.⁶ Respirable particulate\ning slot machines. roulette, black-\nThe field study was performed in\nmeasurements have ranged up to 115\njack. baccarat. craps. and poker. The\nMarch 1996 and consisted of envi-\nµg/m³ in office buildings and up to\ngaming floor has an area of 71.380\nronmental and medical evaluations.\n843 µg/m³ in restaurants.⁷\nsquare feet (ft²): a separate poker\nEmployee representatives and man-"
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