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AGENDA FOR MISSION CONNECT EXECUTIVE PLANNING GROUP
November 8, 1997
Identify the substantive areas and methodologies which should have the highest priority in
plans to further develop spinal cord injury regeneration research at the three medical schools
in Galveston and Houston.
What are the distinct resources and limitations of the research and medical environments at
Baylor College of Medicine, University of Texas Medical School at Houston, and the
University of Texas Medical Branch at Galveston which should be considered in planning
spinal cord injury regeneration research at each of these institutions? Are there features
unique to each institution which favor development of a specific research emphasis or
methodology?
What type of consortium arrangement would enhance the research programs at all three
medical schools and have a synergistic effect ?
How can TIRR contribute to Mission Connect? What types of collaborative research would
be appropriate for TIRR's participation?
Identify clinical research projects which could develop as a result of Mission Connect.
Discuss the funds which are needed over a specific time period to endow the three
laboratories
Discuss specific investigators and laboratories which should be considered in a recruitment
effort
Lex.
10/30
Sat Nov. 8 participants:
199.7085
Tator
Clifton
Grossman
Hulsebosch
Donovan
Grabois
Parsons
Levin
Freden
Lucia
Wolf
Smith
12
Oct 30 97 16:45 No .014 P.01
TEL:713-528-4554
TIRR SYSTEMS
CHARLES H. TATOR, M.D., PH.D.
TIRR
TORONTO HOSPITAL NEUROSCIENCES CENTRE
TIRR was one of the first facilities in the United States to estab-
KEYNOTE SPEAKER, THE MORETON-SPENCER WORKSHOP
ON SPINAL CORD REGENERATION
lish a civilian spinal cord injury center. It was also one of the
first centers to be chosen by the National Institute on Disability
Charles Haskell Tator, program director, Toronto Hospital
and Rehabilitation Research (NIDRR) as a Regional Model
Neurosciences Center since 1993, holds an M.D. and Ph.D.
Spinal Cord Injury System for exemplary patient management
from the University of Toronto and is a Fellow in the Royal
MORETON-SPENCER WORKSHOP
and research, a designation it has maintained since 1972.
College of Surgeons, Canada, and the American College of
The research done at TIRR, a teaching hospital, is enhanced by
ON
Surgeons.
affiliations with both Baylor College of Medicine and The
His previous university and hospital appointments include
SPINAL CORD REGENERATION
University of Texas-Houston Health Science Center.
Head, Division of Neurosurgery and Acute Spinal Cord Injury
TIRR has been recognized every year in a nationwide
Unit, Sunnybrook Medical Centre (1974-84) and Director,
survey of physicians by U.S. News & World Report as one of
NOVEMBER 7, 1997
Canadian Sports Spine and Head Injuries Research Centre,
America's best hospitals.
Toronto Hospital (1985).
Dr. Tator is a member of 14 professional societies and
MISSION CONNECT
TIRR
associations including the Congress of Neurological Surgeons,
Mission Connect is a TIRR-led consortium of the neurosurgery/
(THE INSTITUTE FOR REHABILITATION AND RESEARCH)
American Academy of Neurological Surgery and Canadian
neurosciences departments of Baylor College of Medicine,
TEXAS MEDICAL CENTER
Academy of Sports Medicine. He is on the editorial boards of
The University of Texas-Houston Health Science Center, and
several publications including Neurosurgery and The Journal of
HOUSTON, TEXAS
The University of Texas Medical Branch in Galveston, which
Neurotrauma. He is chairman of the Joint Section of
is committed to finding a cure for the consequences of spinal
Neurotrauma and Critical Care, American Association of
cord injury. Physicians and research scientists from the three
SPONSORED BY
Neurological Surgeons and Congress of Neurological Surgeons.
medical schools have joined forces with TIRR to create this
Dr. Tator's awards include the 1996 Heiner Sell Lectureship
THE MORETON-SPENCER ENDOWMENT
significant effort. The three schools, their enthusiasm to work
Award from the American Spinal Injury Association, and in
in a collaborative manner, and the additional strengths of the
AT
1996 he was a visiting professor at Bordenko Neurosurgical
Texas Medical Center provide the resources necessary to ensure
TIRR FOUNDATION
Institute in Moscow. His numerous research grants include
the first class work the project requires.
"Pathphysiology and Treatment of Acute Spinal Cord Injury"
In the years to come Mission Connect will be a collaborative
by the Medical Research Council and one from the Canadian
effort of multiple academic, health care, and philanthropic
Paraplegic Association. He has been published 211 times and
institutions which will combine resources to develop a world
has edited two books on spinal cord injury.
class research center for spinal cord regeneration.
This November 7 Moreton-Spencer Workshop brings
together scientists from the leading laboratories in the world to
focus on work being done in spinal cord regeneration. They
join representatives from the Mission Connect partners to
contribute their experience and knowledge about the best and
TIRK
most needed niche for Mission Connect's research focus. Once
the goals of the research are defined, applications for project
funding will be sent to all interested Houston-area research
Mission
institutions for evaluation. Seed money to enable project fund-
connect
ing is provided by The TIRR Emily Endowment, established by
TIRR and the Thomas R. Conner family. The endowment hon-
ors the Conners' 20-year-old daughter who was injured a little
over a year ago.
THE MORETON-SPENCER ENDOWMENT
MORNING SCHEDULE
AFTERNOON SCHEDULE
8:00 Continental Breakfast
12:30 Lunch
A
$1 MILLION CONTRIBUTION from the John S. Dunn
8:30 Introductory Comments
Cindy Lucia
Research Foundation in 1991 established an endow-
1:30 Transplant Strategy for SCI Therapeutic Intervention
President, TIRR Foundation
Howard Wolf
Introduction:
William H. Donovan, M.D.
ment to fund research and educational endeavors
Chairman, TIRR
Executive Vice President for Medical
Affairs and Medical Director
related to rehabilitation. The gift is maintained in a perpetual
8:50 Keynote Address
Charles Tator, M.D., Ph.D.
TIRR
The Toronto Hospital
endowment by TIRR Foundation. Earnings are applied to an
Overview of strategies to improve recovery
Lead Facilitator:
Guy Clifton, M.D.
and regeneration in the injured spinal cord
The University of Texas-Houston Medical
annual program to bring rehabilitation experts to TIRR or to
and prospects for clinical application
School
sponsor TIRR Systems staff to visit experts at other facilities.
Co-Facilitator:
Claire Hulsebosch, Ph.D.
9:30 Strategies for Improved Outcome in Spinal Cord Injuries
Ways in which these funds have been used in the past and will
The University of Texas Medical Branch
Introduction:
Kenneth Parsons, M.D.
in Galveston
be in the future include consultation on research projects or
Director, Spinal Cord Injury Program
Presenters:
Mary Bartlett Bunge, Ph.D.
TIRR
programs, speakers on rehabilitation topics, and collaborations
The Miami Project, University of Miami
Lead Facilitator:
William Willis, M.D., Ph.D.
What combination of cells and factors will
of researchers.
The University of Texas Medical Branch
best promote axonal regeneration in adult
in Galveston
mammalian spinal cord
The endowment was named to honor the late Dr. Robert
Co-Facilitator:
David Shine, Ph.D.
Paul Reier, Ph.D.
Dulaney Moreton, executive vice president and medical advisor
Baylor College of Medicine
University of Florida College of Medicine
Presenters:
Marion Murray, Ph.D.
Fetal cell transplants in spinal cord repair
for the John S. Dunn Research Foundation, and Dr. William A.
Allegheny University Health Science
2:30 Break
Spencer, the founder of TIRR.
Center
Serotonergic agents improve transplant
2:45 Genetic and Molecular Approaches to Spinal Cord Injury
Dr. Moreton was vice president emeritus and special assis-
mediated locomotion in rats
Introduction:
Lex Frieden
tant to the president at The University of Texas .D.Anderson
Michaela Thallmair, Ph.D.
Senior Vice President
University of Zurich
TIRR
Cancer Center at the time of his death in December 1992.
Restriction of plasticity and regeneration in
Lead Facilitator:
Ronald Hayes, Ph.D.
the adult CNS by myelin-associated neurite
The University of Texas-Houston Medical
During his 50-year medical career, Dr. Moreton made many
growth inhibitors
School
contributions to the field of diagnostic radiology, improved
Andrew Blight, Ph.D.
Co-Facilitator:
Regio Perez-Polo, Ph.D.
University of North Carolina
The University of Texas Medical Branch in
cancer care, and expanded public health programs. His interest
Inflammatory issues in spinal cord injury
Galveston
in and support of TIRR and its mission as well as his friend-
Claire Hulsebosch, Ph.D.
Presenters:
Dan Liebl, Ph.D.
The University of Texas Medical Branch
The University of Texas Southwestern
ship with Dr. Spencer resulted in meaningful contributions
in Galveston
Medical School
from the John S. Dunn Research Foundation over the years.
Chronic pain after spinal cord injury
Axonal pathfinding in the spinal cord
11:00 Break
Scott Whittemore, Ph.D.
Dr. Spencer founded TIRR in 1959, and guided it to
11:15 Contusion Injury Models of SCI-Model Design for Acute
University of Miami School of Medicine
become a worldwide model for comprehensive medical reha-
Therapeutic Interventions
Neuronal replacement strategies after CNS
trauma
bilitation programs. He began his medical career in 1950 upon
Introduction:
Martin Grabois, M.D.
Executive Vice President
Evan Snyder, M.D., Ph.D.
discharge from the military by establishing the Southwestern
for Medical Policy
The Harvard Medical School
TIRR
Neural progenitor and stem-like cells:
Poliomyelitis Respiratory Center in Houston. Under his leader-
Lead Facilitator:
Robert Grossman, M.D.
Developmental insights may suggest strategies
ship the center gained national recognition for its innovative
for cell replacement and gene therapy in
Baylor College of Medicine
spinal cord and other CNS dysfunctions
and pioneering programs. Those programs were used to estab-
Co-Facilitator:
David McAdoo, Ph.D.
4:00 Closing Comments
Howard Wolf
The University of Texas Medical Branch
Charles Tator, M.D., Ph.D.
lish TIRR, to make the center's rehabilitation expertise available
in Galveston
to people with many kinds of disabilities.
Presenters:
Michael Beattie, Ph.D.
Ohio State University
Strategies for enhancing self-repair of con-
tusion injuries
Thank you to Paralyzed Veterans of America (PVA)
Jean Wrathall, Ph.D.
Georgetown University
for their contribution of breakfast and lunch for today's meeting.
Preserving gray matter and white matter
after spinal trauma
AGENDA FOR MISSION CONNECT EXECUTIVE PLANNING GROUP
November 8, 1997
Identify the substantive areas and methodologies which should have the highest priority in
plans to further develop spinal cord injury regeneration research at the three medical schools
in Galveston and Houston.
What are the distinct resources and limitations of the research and medical environments at
Baylor College of Medicine, University of Texas Medical School at Houston, and the
University of Texas Medical Branch at Galveston which should be considered in planning
spinal cord injury regeneration research at each of these institutions? Are there features
unique to each institution which favor development of a specific research emphasis or
methodology?
What type of consortium arrangement would enhance the research programs at all three
medical schools and have a synergistic effect ?
How can TIRR contribute to Mission Connect? What types of collaborative research would
be appropriate for TIRR's participation?
Identify clinical research projects which could develop as a result of Mission Connect.
Discuss the funds which are needed over a specific time period to endow the three
laboratories
Discuss specific investigators and laboratories which should be considered in a recruitment
effort
From On Levin
He gave copies
to Drs.
oraboist
Grossman
DRAFT
TIRR
TIRR Foundation
Moreton-Spencer Workshop on
Spinal Cord Regeneration
November 7, 1997
Houston, Texas
8:00 am
Continental Breakfast
8:30
Introductory Comments
Cindy Lucia
President, TIRR Foundation
Lloyd Gregory, M.D.
Medical Director, John S. Dunn Research Foundation
Howard Wolf
Chairman, TIRR
8:50
Keynote Address
Charles Tator, M.D., Ph.D.
The Toronto Hospital
9:30
Strategies for Improved Outcome
in Spinal Cord Injuries
Lead Facilitator:
William Willis, M.D., Ph.D.
University of Texas Medical Branch
Co-Facilitator:
David Shine, Ph.D.
Baylor College of Medicine
Presenters:
Andrew Blight, Ph.D.
University of North Carolina
Marion Murray, Ph.D.
Allegheny University Health Science Center
Claire Hulsebosch, Ph.D.
University of Texas Medical Branch
11:00
Break
11:15
Contusion Injury Models of SCI -
Model Design for Acute
Therapeutic Interventions
Lead Facilitator:
Robert Grossman, M.D.
Baylor College of Medicine
Co-Facilitator:
David McAdoo, Ph.D.
University of Texas Medical Branch
Presenters:
Michael Beattie, Ph.D.
Ohio State University
Jean Wrathall, Ph.D.
Georgetown University
12:30 pm Lunch
1:30
Transplant Strategy for
SCI Therapeutic Intervention
Lead Facilitator:
Guy Clifton, M.D.
University of Texas-Houston Medical School
Co-Facilitator:
Claire Hulsebosch, Ph.D.
University of Texas Medical Branch
Presenters:
Mary Bunge, Ph.D.
The Miami Project, University of Miami
Paul Reier, Ph.D.
University of Florida College of Medicine
2:30
Break
2:45
Genetic and Molecular
Approaches to Spinal Cord Injury
Lead Facilitator:
Ronald Hayes, Ph.D.
University of Texas-Houston Medical School
Co-Facilitator:
Regio Perez-Polo
University of Texas Medical Branch
Presenters:
Luis Parada, Ph.D.
Univ. of Texas Southwestern Medical School
Scott Whittemore, Ph.D.
University of Miami School of Medicine
Evan Snyder, M.D., Ph.D.
The Harvard Medical School
4:00
Closing Comments
Howard Wolf
Charles Tator, M.D., Ph.D.
1
2
1w
3
4
"I
5
Wolf
Grossman
Nov 05 97 13:33 005 No.005 P.02
Hayes
Hulsebosch
Clifton
Wolf
Grossman
Hayes
Frieden
Clifton
Tator
Lucia
Smith
Frieden
Beall
Lucia
Hudgins (PVA)
Smith
Frieden
Beall
Donovan
Grabois
Dice
Levy
Parsons
Donoven
Grabois
Dice
Bunge
Parsons
Dalecki
rLiebl
-Reier
wrathall
Levin
Dalecki
Murray
Snyder
Shenag
Levin
Blight
Thailmair
Beattie
Rabinorski
100
-
8
TEL :713-528-4554
5
G
M
PP
* Howard requested that he sit with these 2.
TIRR SYSTEMS
Roxy. Rex's office
10Am Thursday
Memorandum
To:
Mission Connect Medical Advisory Committee
DRAFT
From:
Cindy Lucia
Date:
September 30, 1997
Re:
Moreton-Spencer Workshop on Spinal Cord Regeneration
The attached letter and agenda were sent to our guest speakers for the November 7 Moreton-Spencer
Workshop on Spinal Cord Regeneration. Please make certain that your calendars are reserved for
the following dates:
Thursday, November 6 7 pm until midnight
Hand in Hand with Hope (TINC) fund raising event
Edwin Hornberger Conference Center
Invitation Enclosed
Friday, November 7
8 am until 5 pm
Moreton-Spencer Workshop
TIRR Conference Rooms 2A & B
Friday, November 7
6:30 pm until 8:30 pm
Workshop Participant Thank You Dinner
Wyndham Warwick - Tapestry Room
As a member of the Medical Advisory Committee, you will be the guest of TIRR Foundation at each
of these events. You are invited to bring a guest to the Thursday event; the Friday dinner is for
committee members only.
Attached is the list of individuals who will be invited to the Workshop; these names have been
submitted in large part by our committee and I would appreciate it if you would verify that this list is
inclusive of all the appropriate parties. Please respond to me with any additions/changes by
Wednesday, October 8.
Also included is a registration form so that I can plan for the correct number of individuals at each
of these events. Please complete and return to me in the enclosed envelope by October 10. Thanks
for your help.
workshop facilitator responsibilities
L- Would you help me make certain that I have etc included
all the info here that's reeded? also, wording
should you, Hawey l mut Thurs(ish) so We can ex? severy
when we are vis-a-vis the Conference and invitations,
TIRR Foundation
5100 Travis
TIRR
Houston, Texas 77002-9746
Telephone (713) 528-0123
Fax (713) 528-4554
September 18, 1997
«FirstName» «LastName»
«Address1»
«Address2»
«Address3»
«Address4»
«City», «State» «PostalCode»
Dear Dr. «Dear»:
TIRR Foundation announced our commitment to initiate a research project focused on spinal cord
regeneration, named Mission Connect, in a press conference August 26. The coverage we got
locally was great and indicates the community's interest in this project. One of the items which
received attention is the Moreton-Spencer Workshop on Spinal Cord Regeneration Research, our
November 7th conference to be held at TIRR in the Texas Medical Center.
As you prepare for participation in this workshop, please review the enclosed outline for the day.
We are asking that each investigator focus his/her remarks to address the following questions:
1) Why did you select the model used in your experimental design?
2) What are the outcomes used to measure the success of interventions?
3) What are the clinical implications of your work?
4) What do you speculate will be among the most promising interventions for acute SCI and for
chronic SCI?
5) Do you have any suggestions on specific changes in current laboratory, preclinical and clinical
research strategies that would allow more rapid movement of successful therapies from the
laboratory to the patient?
6) Do you see any current impediments to the rapid development of therapies for spinal cord
injury? If so, how can these impediments be overcome?
Each presenter should speak for no more than 15 minutes and the facilitators will lead a 30 minute
question and answer period following each topic's review. While not required, if you plan to use
slides and/or wish to distribute a manuscript which is most representative of you current work,
please send me a copy so that I can reproduce sets for our audience. Also, please let me know the
title of your talk for inclusion in our agenda.
Included is a registration form for the dinners we hope you will attend and for hotel reservations.
Please complete and return in the envelope provided by October 10. As noted previously, TIRR
Foundation is delighted to pay for expenses related to your trip. Please submit an expense report
at the above address.
Thank you for your involvement in Mission Connect; I look forward to meeting you in November.
Sincerely,
Cindy Lucia
Executive Director
TIRR Foundation
TIRR
5100 Travis
Houston, Texas 77002-9746
Telephone (713) 528-0123
Fax (713) 528-4554
TIRR Foundation
Moreton-Spencer Workshop on
Spinal Cord Regeneration
November 7, 1997
Houston, Texas
Introductory
Howard Wolf
Chairman, TIRR
Keynote
Charles Tator, M.D., Ph.D.
The Toronto Hospital
Strategies for Improved Outcome
in Spinal Cord Injuries
Facilitators:
William Willis, M.D., Ph.D.
University of Texas Medical Branch
David Shine, Ph.D.
Baylor College of Medicine
Presenters:
Barbara Bregman, Ph.D.
Georgetown University School of Medicine
Andrew Blight, Ph.D.
University of North Carolina
Marion Murray, Ph.D.
Allegheny University Health Science Center
Claire Hulsebosch, Ph.D.
University of Texas Medical Branch
Contusion Injury Models of SCI -
Model Design for Acute
Therapeutic Interventions
Facilitators:
Robert Grossman, M.D.
Baylor College of Medicine
David McAdoo, Ph.D.
University of Texas Medical Branch
Presenters:
Michael Beattie, Ph.D.
Ohio State University
Jean Wrathall, Ph.D.
Georgetown University
Transplant Strategy for
SCI Therapeutic Intervention
Facilitators:
Guy Clifton, M.D.
University of Texas-Houston Medical School
Claire Hulsebosch, Ph.D.
University of Texas Medical Branch
Presenters:
Mary Bunge, Ph.D.
The Miami Project, University of Miami
Paul Reier, Ph.D.
University of Florida College of Medicine
Genetic and Molecular Approaches
to Spinal Cord Injury
Facilitàtors:
Ronald Hayes, Ph.D.
University of Texas-Houston Medical School
Regio Perez-Polo
University of Texas Medical Branch
Presenters:
Luis Parada, Ph.D.
Univ. of Texas Southwestern Medical School
Scott Whittemore, Ph.D.
University of Miami School of Medicine
Evan Snyder, M.D., Ph.D.
The Harvard Medical School
Adjourn
Howard Wolf
Charles Tator, MD., Ph.D.
TIRR FOUNDATION
MORETON-SPENCER WORKSHOP ON
SPINAL CORD REGENERTION
November 1997
Registration Form
Committee Member
Mark below if your plans are to attend, so that appropriate reservations can be made.
Hand in Hand with Hope Country Western Event
Thursday, November 6, 7 p.m. until midnight, Edwin Hornberger Conference Center
This is our kick-off fund raiser and will include a barbecue dinner and entertainment by
one of Texas' favorite entertainers, Jerry Jeff Walker. Silent and live auction; "western
chic" attire.
Moreton-Spencer Workshop on Spinal Cord Regeneration
Thursday, November 6, 8 a.m. until 5 p.m., TIRR conference Rooms 2 A & B.
Workshop Participant Thank You Dinner
Friday, November 7, 6:30 p.m. until 8:30 p.m.
Representatives from TIRR, Baylor College of Medicine, The University of Texas-
Houston Health Science Center, and The University of Texas Medical Branch in
Galveston will host our workshop participants to dinner at the Wyndham Warwick.
Please return to Cindy Lucia in the attached envelope by October 10.
NCSCI Editorial
for
UNITED
July, 1997
The National Council on Spinal Cord Injury
NB: In order to take maximum advantage of the current budget
There is considerable evidence that medical science has
debate focus on Medicare, NCSCI has forwarded the following
already launched us on a trajectory of steadily improving
opinion piece to members of the Senate and House
health among people over 65. The recently-published Duke
Appropriations Committees, and to other key Members of
Congress. Although the individual Institutes of Health receive
University disability survey tracked Medicare records of
increases of differing amounts when the overall NIH is increased
35,000 recipients from 1982-94, observing an average
(Cancer, Infectious Diseases and Heart-Lung generally fare best),
annual decline in chronic disability of 1.3% 14% over the
the proposed doubling of the overall budget would bring the
12-year period. Because there were 1.2 million fewer
Neurological Institute well over a billion dollars.
disabled in 1995 than projected in 1982, it is estimated that
Medicare spent $25 billion less than expected in 1995
alone.
A new study from the University of Miami and the Miami
VA ("The Medicare-HMO Revolving Door: The Healthy
Research-driven health improvements not only allow us to
Go in and the Sick Go Out," New England Journal of
redefine the aging process but impel us to recalculate
Medicine, July 17) suggests that Medicare recipients
aging-related health care costs. New technology and
frequently abandon assigned HMOs in favor of fee-for-
breakthrough drugs mean that conditions once requiring
service care when they become ill. It concludes that
major surgery can now be treated much less invasively and
managed care might not be able to deliver the expected
with fewer complications (knee and gall bladder surgery),
Medicare savings over the long run because Medicare ends
eliminated with antibiotics (peptic ulcers), treated with off-
up footing the bill for the sickest of the sick. This report
label use of existing drugs (ACE-II inhibitors, originally
adds yet another dimension to recent stories of legislative
intended for hypertension, instead of renal dialysis) or best
efforts nationwide to prop up HMO patients' rights and to
of all, prevented with existing drugs (exogenous estrogen to
reports of organized physician resistance to erosion of the
protect against osteoporosis, heart disease and Alzheimers;
doctor-patient relationship under the managed care model.
low-dose aspirin taken daily to protect against heart disease
and stroke). These treatment directions all lead to far lower
Backlash against "bottom-line medicine" is mounting on all
costs.
fronts, which means Congress must go back to the drawing
board to find ways to reform Medicare in a way that
As we achieve even greater understanding of human
maintains high-quality health care for a growing elderly
biological processes, we will genetically intervene in
population, at a price the nation can afford.
disease before symptoms appear or prevent disease with
simple dietary alterations. For example, it is now known
Recent proposals to raise the Medicare eligibility age and
that added vitamin C and E can delay the onset of cataracts
assess higher premiums from affluent recipients are
by ten years, potentially eliminating the need for up to 50%
necessary first steps on the cost side of the reform process.
of cataract surgeries -- one of the iargest Medicare line
To successfully address the long-term problem, however,
items. Researchers estimate that if optimum doses were
these cost-side steps must. be bolstered by a more profound
known and publicized by the year 2000, $392 billion could
demand-side strategy: the doubling of appropriations to the
be saved in this one area between 2000 and 2040 (1991
National Institutes of Health. If we raise our national
dollars, and assuming 5% annual inflation). Other
commitment to accelerating the pace of biomedical
opportunities for similar savings abound.
research now, we will hasten the timetable by which
researchers can delay, cure or prevent many of the costly
Medicine has undergone a revolution a virtual explosion
aging-related diseases that drive Medicare. The bottom line
of new knowledge -- in the past decade. The coming
is that a healthier elderly population will demand less from
decades will see the elimination of many of the most costly
the health care system. Since chronically-ill people cost six
chronic afflictions associated with aging -- thereby
times more than healthy people, even the impending
increasing productivity, saving lives and saving billions of
doubling of the over-65 population will not outstrip the
Medicare dollars. Policy planners in Washington will get us
potential savings.
there faster by investing in medical research today.
151 Tremont Street Boston, MA 02111 Phone 617-338-7777 Fax 617-338-4266
D RAFT
TIRR FOUNDATION
MORETON-SPENCER WORKSHOP ON
SPINAL CORD REGENERTION
November 1997
Audience Guest List
Baylor College of Medicine
Robert Grossman, M.D., committee member
Brian Baumgartner, Ph.D.
Philip Liu, Ph.D.
Claudia Robertson, M.D.
David Shire, Ph.D.
Richard Simpson, M.D., Ph.D.
David Yoshar, M.D.
University of Texas-Houston Medical School
John Byrne, Ph.D., committee member
Guy Clifton, M.D., committee member
Ron Hayes, Ph.D., committee member
Carrie Markgraf, Ph.D.
Keyi Yang, M.D., Ph.D.
University of Texas Medical Branch in Galveston
Richard Coggeshall, M.D., committee member
Claire Hulsebosch, Ph.D., committee member
Hank Nauta, M.D., committee member
Bill Willis, M.D., Ph.D., committee member
David McAdoo, Ph.D.
Regio Perez-Polo, Ph.D.
TIRR
Bill Donovan, M.D., committee member
Marty Grabois, M.D., committee member
Lex Frieden, committee member
Harvey Levin, Ph.D., committee member
Ken Parsons, M.D., committee member
Louisa Adelung
Charlie Beall
Ed Carter, M.D.
Lyn Emerich
Saleh Shenaq, M.D.
Ashley Smith
TIRR Trustees
Greg Abbott
Jerry Andrew
Paul Frison
Bob Sale
Bud Shivers
Howard Wolf
Community Representatives
Conner Family, former patient and family
Robert Davis, former patient
Lloyd Gregory, M.D., Dunn Foundation
Lisa Hudgins, Paralyzed Veterans of America
Bill W. Lloyd, former patient
Bill R. Lloyd, J. M. West Texas Corp.
Skip Porter, HARC
Michele Sabino, Houston Endowment
Pete Seale, Smith Foundation
Dick Wainerdi, Ph.D., Texas Medical Center
Kent Waldrep, Kent Waldrep National Paralysis Foundation
Glenn Welsch, former patient
Others
Shirley Barr, PR representative
Susan Farb, PR representative
SEP.29.1997 2:28PM TIRR HOSPITAL
NO.761
P.2/2
TIRR Trustees
Greg Abbott
Jerry Andrew
Paul Frison
Bob Sale
Bud Shivers
Howard Wolf
Community Representatives
Conner Family, former patient and family
Robert Davis, former patient
Lloyd Gregory, M.D., Dunn Foundation
Lisa Hudgins, Paralyzed Veterans of America
Bill W. Lloyd, former patient
Bill R. Lloyd, J. M. West Texas Corp.
Michele Sabino, Houston Endowment
Pete Seale, Smith Foundation
Dick Wainerdi, Ph.D., Texas Medical Center
Kent Waldrep, Kent Waldrep National Paralysis Foundation
Glenn Welsch, former patient
Others
Shirley Barr, PR representative
Susan Farb, PR representative
SEP.29.1997
2:28PM
TIRR HOSPITAL
NO.761
P.1/2
TIRR FOUNDATION
MORETON-SPENCER WORKSHOP ON
SPINAL CORD REGENERTION
November 1997
Audience Guest List
Baylor College of Medicine
Robert Grossman, M.D., committee member
Brian Baumgartner, Ph.D.
Philip Liu, Ph.D.
Claudia Robertson, M.D.
David Shire, Ph.D.
Richard Simpson, M.D., Ph.D.
David Yoshar, M.D.
University of Texas-Houston Medical School
John Byrne, Ph.D., committee member
Guy Clifton, M.D., committee member
Ron Hayes, Ph.D., committee member
Carrie Markgraf, Ph.D.
Keyi Yang, M.D., Ph.D.
University of Texas Medical Branch in Galveston
Richard Coggeshall, M.D., committee member
Claire Hulsebosch, Ph.D., committee member
Hank Nauta, M.D., committee member
Bill Willis, M.D., Ph.D., committee member
David McAdoo, Ph.D.
Regio Perez-Polo, Ph.D.
TIRR
Bill Donovan, M.D., committee member
Marty Grabois, M.D., committee member
Lex Frieden, committee member
Harvey Levin, Ph.D., committee member
Ken Parsons, M.D., committee member
Louisa Adelung
Charlie Beall
Ed Carter, M.D.
Lyn Emerich
Saleh Shenaq, M.D.
Ashley Smith
TIRR Foundation
5100 Travis
TIRR
Houston, Texas 77002-9746
Telephone (713) 528-0123
Fax (713) 528-4554
September 18, 1997
Dear Dr.
TIRR Foundation announced our commitment to initiate a research project focused on spinal cord
regeneration, named Mission Connect, in a press conference August 26. The coverage we got
locally was great and indicates the community's interest in this project. One of the items which
received attention is the Moreton-Spencer Workshop on Spinal Cord Regeneration Research, our
November 7th conference to be held at TIRR in the Texas Medical Center.
As you prepare for participation in this workshop, please review the enclosed outline for the day.
We are asking that each investigator focus his/her remarks to address the following questions:
1) Why did you select the model used in your experimental design?
2) What are the outcomes used to measure the success of interventions?
3) What are the clinical implications of your work?
4) What do you speculate will be among the most promising interventions for acute SCI and for
chronic SCI?
5) Do you have any suggestions on specific changes in current laboratory, preclinical and clinical
research strategies that would allow more rapid movement of successful therapies from the
laboratory to the patient?
6) Do you see any current impediments to the rapid development of therapies for spinal cord
injury? If so, how can these impediments be overcome?
Each presenter should speak for no more than 15 minutes and the facilitators will lead a 30 minute
dialogue following each topic's review. While not required, if you plan to use slides and/or wish
to distribute a manuscript which is most representative of you current work, please send me a copy
so that I can reproduce sets for our audience. Also, please let me know the title of your talk for
inclusion in our agenda.
Included is a registration form for the dinners we hope you will attend and for hotel reservations.
Please complete and return in the envelope provided by October 10. As noted previously, TIRR
Foundation is delighted to pay for expenses related to your trip. Please submit an expense report
at the above address.
Thank you for your involvement in Mission Connect; I look forward to meeting you in November.
Sincerely,
Cindy Lucia
Executive Director
HAND IN HAND WITH HOPE
Benefitting
The TIRR Emily Endowment
The Institute for
Rehabilitation and Research
HAND IN HAND
A Country - Western Evening
with Barbecue Dinner and Dancing
Live and Silent Auctions
Starring
JERRY JEFF WALKER
The TIRR Emily Endowment was established to raise $1 million
also featuring
in seed funds to begin research in the Houston-Galveston area
The Cowboy Jazz Band
focused on spinal cord regeneration. Working together with
Baylor College of Medicine, The University of Texas-Houston
Thursday, November 6, 1997
Health Science Center, and The University of Texas Medical
7 p.m. until Midnight
Branch at Galveston, TIRR is committed to developing one of
the country's premier research projects dedicated to healing
The Edwin Hornberger
Conference Center
the consequences of spinal cord injury. This effort honors Emily
(formerly the Shamrock Hotel Ballroom)
Conner, recognizing her personal commitment to recover fully
2151 West Holcombe
from her spinal cord injury, sustained in 1996.
Attire:Western Chic
TIRR
Dear Friends,
The response to our first Hand In Hand With
Hope event has been overwhelming. Due to the
generous support of our underwriters, we are
pleased to announce the event is sold out.
If you would like to be placed on a waiting list
in the event seats become available, or if you
would simply like to make a contribution to
TIRR Foundation, please indicate your wish on
the RSVP card.
Thank you for your commitment to make a differ-
ence in the lives of individuals in our community
with spinal cord injuries. Your generous support
will provide funding needed for spinal cord
research.
For more information about TIRR Foundation,
call (713) 528-0123.
Thank you.
Marsha and Jim Braniff
Bobbie and John Nau
TIRR Foundation
Hand in Hand with Hope
Underwriters
TRAIL BOSSES
WRANGLERS
The Les Allison Family & Greenwood-King Properties
Mrs. Nancy C. Allen
and The Lee Matherne Family & Premier, Inc.
The Allibone Family
Jerry Johnston Andrew
Kathi & John Arnoldy
Arthur Andersen LLP
Marsha & Jim Braniff/Bobbie & John Nau
Beutel, Goodman Capital Management
Brochstein Foundation, Inc.
Cam & Rod Canion
Charter Title Company
Anne & Tom Conner
Nancy & Russell Cook
The Garwood Family
Compass Bank
Gillson-Longenbaugh Foundation
Deloitte & Touche L.L.P. and Deloitte & Touche
Glazier Foods Company
Consulting Group
The MacDonald-Peterson Foundation
Mr. & Mrs. Tom Dompier
Silver Eagle Distributors/Budweiser
Jack Heard/Paul Somerville
Dunn, Kacal, Adams, Pappas & Law, P.C.
Mr. Arthur Epley
Spindletop Charities, Inc.
Susanne & Randall Evans
Strake Foundation
Friends of Emily
Mrs. Wesley West
Marion Guill
Anonymous
Gulf States Financial Services
Chris Hamm/Oppenheimer
TOP HANDS
Hand in Hand
American General Corporation
Adele & Dan Hedges
BMS Management, Inc.
Helm Pletcher Bowen & Saunders L.L.P.
J. C. Bradford & Co.
Home Mortgage Consultants, Inc.
Brown, Parker & Leahy, L.L.P.
Houston National Bank
Commonwealth Land Title Company of Houston
Julie & Tommy Hughes
DeMontrond-Montalbano-White
Judy & John Hutchison
Ray C. Fish Foundation
Fulbright & Jaworski L.L.P.
Mr. & Mrs. Drew Lewis, Mary Pate, Neal Myers
Jane & Rick McCord
R. T. Herrin, Sr.
Daniel A. Hyde
Cora Bess & John Stirling Meyer, M.D.
Judy & Peter Meyer, Peto & John
Liddell, Sapp, Zivley, Hill & LaBoon, L.L.P.
Robin & Jim Livesay
Natural Gas Storage Corporation of North America
Richard Mithoff
Joe, Kathy, Rebecca & Forrest Redden
Fairfax & Risher Randall
Paula & Butch Robinson and Linda & Jim Epps
Nancy & Clive Runnells
L.E. Simmons Family Foundation
Robin & Bud Shivers
Union Texas Petroleum
Dick Watt
Mr. Thomas D. Simmons, Jr., Dudley & Alexandra
Southwest Guaranty Trust Co.
John E. Williams, Jr.
Supporters of TIRR
Glenys & Howard Wolf
Texas Commerce Bank
Dept. of Neurosurgery, University of Texas-Houston
Health Science Center
Steve Waldman/Grossman & Waldman, L.L.P.
Watkins Carter Hamilton
Thanks to our underwriters
Mr. & Mrs. W. M. Wheless III and
who contributed after
Mr. & Mrs. James C. Gordon
the printing deadline.
Glenn Welsch
Lois & Brad Wright
Paul R. & Susan T. Young
TIRR Foundation
Hand in Hand with Hope
Committee Members
Honorary Chairman
Mr. Brian Fox
Ms. Margaret Miller
Mrs. Jerry Johnston Andrew
Mr. & Mrs. Russell Frankel
Mr. & Mrs. John J. Montalbano
Mr. & Mrs. Richard Fuqua
Ms. Victoria Nau
Event Chairmen
Ms. Lindsay Gaido
Mr. & Mrs. Dallas Parker
Mr. & Mrs. James J.
Mr. & Mrs. S. J. Gaido III
Ms. Meredith Pierce
Braniff III
Ms. Susan Garwood
Dr. & Mrs. Mike Pierce
Mr. & Mrs. John L. Nau III
Mr. & Mrs. Calvin B.
Mr. & Mrs. Leo Reichle
Committee Members
Garwood III
Ms. Emilly Robins
Mr. & Mrs. Les Allison
Mr. & Mrs. Hart Goodrich
Mr. & Mrs. Butch Robinson
Mr. & Mrs. Ray B. Bailey
Ms. Kay Gregg
Mr. & Mrs. Robert N. Ross
Mr. & Mrs. Robert Bates
Dr. & Mrs. Frank Hadlock
Mr. & Mrs. Robert P. Ross, Jr.
Mr. & Mrs. John R. Braniff, Sr.
Ms. Carol Harper
Mr. & Mrs. Clive Runnells
Mr. John R. Braniff, Jr.
Mr. & Mrs. Jack Heard, Jr.
Mr. Pierce Runnells
Ms. Karen Bridges
Ms. Patty Henry
Mr. & Mrs. Clive Runnells III
Ms. Bridget Burke
Mr. Trent Henry
Mr. Stewart Schaefer
Ms. Jennifer Burke
Ms. Kristen Holland
Mr. & Mrs. Patrick J. Scherriebb
Ms. Lillie Byrd
Mr. & Mrs. Robin Holland
Mr. & Mrs. Michael Schiener
Mr. & Mrs. J. Rod Canion
Ms. Cathryn Holmsley
Mr. & Mrs. John Sharman
Mr. Ross Canion
Ms. Cindy Hood
The Honorable & Mrs. John
Mr. & Mrs. Larry L. Carroll
Mr. & Mrs. Tommy Hughes
Singleton
Mr. & Mrs. Scott Caven
Judge & Mrs. John A.
Mr. James Patrick Smith
Mr. Louis Clepper
Hutchison III
Mr. & Mrs. Paul G. Somerville
Mr. & Mrs. Thomas R. Conner
Ms. Cheryl Jeter
Ms. Linda Stout
Mr. Will Conner
Mr. Dan King
Mrs. Missa Sutton
Ms. Jan Crane
Mr. Chris Lewis
Mr. Dudley Tarlton
Mr. John Crapitto
Mr. Sonny Lewis
Ms. Kathy Taylor
Mr. & Mrs. Louis Crapitto
Mr. Ted Lyons
Ms. Cheryl Thomas
Mrs. Lynn Cutrer
Mr. Jerry Mabry
Mr. & Mrs. James D.
Mr. & Mrs. James D.
Mr. & Mrs. Robert S.
Verbois, Jr.
Dannenbaum
Maclntyre, Jr.
Mr. Travis Walne
Mr. & Mrs. George DeMontrond
Ms. Shannon Macintyre
Mr. & Mrs. William M.
Ms. Melissa DeMontrond
Mr. Thomas R. McDade
Wheless III
Ms. Peggy DeMontrond
Mrs. Becky McFarland
Ms. Constance White
Mr. & Mrs. Tom Dompier
Ms. Molly McFarland
Mr. & Mrs. Bill Whitworth
Cora Bess & John S.
TIRR Foundation
Ms. Linda Evans
Ms. Elise Wilkinson
Hand in Hand with Hope
Mr. & Mrs. Randall Evans
Meyer, M.D.
Mr. John Eddie Williams
Select Auction Items
Mrs. Carolyn Faulk
Mr. John Meyer
Mr. Len Wolowiec
Ms. Haley Fergeson
Mr. Peto Meyer
Mr. & Mrs. Jon W. Young
Mr. & Mrs. Jeffery B. Firestone
Ms. Judy Meyer
We are excited to announce the following as some of our auction items.
Photographic Safari
Experience the great physical drama of a seven day safari in Botswana. Package for four
includes accommodations on the safari and round trip airfare from Houston on South
African Airlines/American Airlines. Bidder assumes airfare from Johannesburg to and
from the camp. Safari available in September 1998. Donated by the Les Allison Family,
Peter Hepburn Photographic & Hunting Safaris, Peter Holbrow of Elephant Back Safaris.
Dove Hunt
An opening weekend dove hunt for eight at the incredible Tres Hijos Ranch a 3,500 acre
ranch in McMullen County, South Texas. Private King Air transportation, ranch house,
indoor pool, food and beverages included. Expires November 30, 1998. Donated by
Tom Conner, Bub Epley, Dick Fuqua, Aviex Jet, Inc.
Opryland
Experience the thrill of Opryland during the Country Music Festival in June 1998. This
package for four includes King Air transportation, lodging, and backstage passes to see
Tracy Lawrence. Donated by Jack and Janet Heard.
Afternoon Cruise
Fabulous day cruise on the Lady Raye, an 83 foot Broward, docked at Lakewood Yacht
Club in Clear Lake. Buffet luncheon and beverages for eight couples who will truly enjoy
a wonderful experience. Group transportation from the host's home. Expires September
1998. Donated by Ed and Raye White; catered by Marilyn and George DeMontrond.
Caribbean Cruise
Six island hoppers will enjoy cruising the crystal blue Caribbean waters for five days
aboard a 48 foot power yacht. Your days will be filled with fishing, scuba, snorkeling,
or sight seeing. Excludes Captain (available $100 per day), fuel, provisions, and insurance.
Cruise will accommodate four if Captain is included. Available May through December
1998, with a holiday block. Donated by V.I.P. Yacht Charters/Frank and Connie Jordan.
TIRR
Memorandum
To:
Mission Cindy Lucia Connect-Medical anythan
Advisory Committee
From:
Date:
October 13,
Re:
Moreton-Spencer Workshop on Spinal Cord Regeneration
The attached letter and agenda were sent to our guest speakers for the November 7 Moreton-Spencer
Workshop on Spinal Cord Regeneration. Pleasé make certain that your calendars are reserved for
the following events that you plan to attend:
Thursday, November 6
7 pm until midnight
Hand in Hand with Hope fund raising event
Edwin Hornberger (TMC) Conference Center
Invitation Enclosed
Friday, November 7
8 am until 5 pm
Moreton-Spencer Workshop
TIRR Conference Rooms 2A & B
Friday, November 7
6:30 pm until 8:30 pm
Workshop Participant Thank You Dinner
River Oaks Country Club - Green Room
Saturday, November 8
9 am until 1 pm
Mission Connect Executive Planning Group
TIRR Conference Rooms 2A & B
As a member of the Medical Advisory Committee, you will be the guest of TIRR Foundation at each
of these events. You are invited to bring a guest to the Thursday event and Friday's dinner. Please
note that the Thursday fund raising event is sold out and may be standing room only.
Attached is the list of individuals who will be invited to the Workshop; these names have been
submitted in large part by our committee and I would appreciate it if you would verify that this list is
inclusive of all the appropriate parties. Please respond to me with any additions/changes by
Wednesday, October 15.
Each section of the agenda has a lead and co facilitator. It will be the responsibility of these
individuals to introduce the speakers in their panel, to control the time each presenter speaks (we've
asked everyone to limit their comments to 15 minutes) and, after the presentations, to lead the entire
group in a dialogue focusing on the six questions which were suggested to be addressed and/or any
other pertinent ideas.
Also included is a registration form SO that I can plan for the correct number of individuals at each of
these events. Please complete and return by mail or fax by October 15. Thanks for your help.
TIRR
TIRR FOUNDATION
MORETON-SPENCER WORKSHOP ON
SPINAL CORD REGENERATION
November 1997
Audience Guest List
Baylor College of Medicine
Robert Grossman, M.D., committee member
Brian Baumgartner, Ph.D.
Ralph D. Feigin, M.D.
Philip Liu, Ph.D.
Claudia Robertson, M.D.
David Shine, Ph.D.
Richard Simpson, M.D., Ph.D.
David Yoshar, M.D.
University of Texas-Houston Medical School
John Byrne, Ph.D., committee member
Guy Clifton, M.D., committee member
Ron Hayes, Ph.D., committee member
David Low, M.D., Ph.D.
Carrie Markgraf, Ph.D.
Keyi Yang, M.D., Ph.D.
University of Texas Medical Branch in Galveston
Richard Coggeshall, M.D., committee member
Claire Hulsebosch, Ph.D., committee member
Hank Nauta, M.D., committee member
Bill Willis, M.D., Ph.D., committee member
Thomas N. James, M.D.
David McAdoo, Ph.D.
Regio Perez-Polo, Ph.D.
TIRR
Bill Donovan, M.D., committee member
Marty Grabois, M.D., committee member
Lex Frieden, committee member
Harvey Levin, Ph.D., committee member
Cindy Lucia, committee member
Ken Parsons, M.D., committee member
Louisa Adelung
Charlie Beall
Ed Carter, M.D.
Sherry Dunbar
Lyn
Emerich
M.D.
Mary TIRR Karen Ashley Saleh Greg Cindy Abbott Shenaq, Koch Trustees Ivanhoe, Hart Smith
M.D.
Jerry Andrew
Paul Frison
Bruce LaBoon
Bob Sale
Bud Shivers
Howard Wolf
Community Representatives
Conner Family, former patient and family
Robert Davis, former patient
Lloyd Gregory, M.D., Dunn Foundation
Lisa Hudgins, Paralyzed Veterans of America
Lawrence Levy, Gillson Longenbaugh Foundation
Bill W. Lloyd, former patient
Bill R. Lloyd, J. M. West Texas Corp.
John Mendelsohn, M. D. Anderson
Skip Porter, HARC
Michele Sabino, Houston Endowment
Pete Seale, Smith Foundation
Dick Wainerdi, Ph.D., Texas Medical Center
Kent Waldrep, Kent Waldrep National Paralysis Foundation
Glenn Welsch, former patient
Others
Shirley Barr, PR representative
Susan Farb, PR representative