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December 18, 1925.
Dr. F. B. Flinn,
437 West 59th Street,
Columbia University,
New York City.
Dear Dr. Flinn:-
I am herewith sending you a copy of the report of the tests made
on Mrs Mallifer's bone. The final values are much higher than
my first estimate, which evidently were wrong someplace. On
this basis Martland's estimate was not so far wrong.
I am also enclosing report on the three guinea pigs so far
received.
With the Beasons "reetings, I am,
Yours truly,
H. H. Barker.
Experiemtns on the Determination of the Rate of
Excretion of Radium Solutions Intravenously
into Guines Pigs.
Standard 5 microgram ampoules as put up by the U. S. Radium
Corporation were used for the injections.
Experiment 1. 15 minutes after bue injection had been made the
one of the D1gs was killed and incinerated, weight of ash, 24.81 &
Radium found--- 4.19, and 4.23, average 4.21 micrograms.
Experiment 2. 24 hours after the injection one p1g was killed
and incinerated, weight of ash, 21.39 grams.
Radium found, 3.7, 3.7, and 3.8, average, 3.73 micrograms.
Experiment 3. 48 hours after the injection one pis was killed
and incinerated, weight of ash, 21.15 grams. Rediumsfoun
Radium found, 3.00, 3.28, and 3.18, average 3.15 micrograms.
It seems to me that in computing the rate of excretion we should
use the quantity of radium found in the pig killed after 15
minutes after the injection rather than the theoretical quantity
of 5 micrograms in the ampoule.
H.H. Barker.
Physical Laboratory,
December 18, 1925.
Sample of Bone Cortex and Marrow Taken from
The Femurs of Mrs Mallifer.
These samples were handed to Mr. Viedt and
myself by Dr. Martland shortly after
November 1, 1925.
The al gauna rayactivity was measured on a sample containing
weighing 60.2 grans and expressed in terms of radium equivalent.
The actual radium present was determined by the emanation method.
Gamma ray measurements O1 the tube containing 60.2 grams.
11/13
0018 mg.
12/4
0010
11/16
0021
12/9
0011
11/18
0014 "
12/14
.0020
11/20
0015 #
12/16
0014
average of .0015 mg. or 2.5 X 10-5 mg per gram.
Assuming the total weight of the bone in the body to be 13/16
of that in Leman's body (9800 grams) and that this sample 1s
repres entative of the total, we calculate the total quantity
of radium equivalent contained in the body to be 199 micrograms.
The smanation values determined were as follows:-
7.45 X 10⁻⁶ mg. per gram.
7.50
If
"
"
11
7.58
#
11
11
it
7.61
"
=
14
=
7.60
If
11
=
10
7.55
11
#
"
a
average.
13/16 X 9800 X 7.55 X 10-6 gives 60 micragrams of radium element
It thus appears that about 30 percent of the total activity can
be ascribed to radium while the balance or 70 percent must be
ascribed to mesothorium or radiothorium.
H. 8. Barker.
Physical Laboratory,
U. S. Radium Corporation,
December 18, 1925.
Experiemtns on the Determination of the Rate of
Excretion of Radium Solutions Intravenously
into Guines Pigs.
Standard 5 microgram ampoules as put up by the U. S. Radium
Corporation were used for the injections.
Experiment 1. 15 minutes after the injection had been made the
one of the pigs was killed and incinerated, weight of ash, 24.81 &
Radium found. 4.19, and 4.23, average 4.21 micrograms.
Experiment 2. 24 hours after the injection one pig was killed
and incinerated, weight of ash, 21.39 grams.
Radium found, 3.7, 3.7, and 3.8, average, 3.73 micrograms.
Experiment 3. 48 hours after the injection one pig was killed
and incinerated, weight of ash, 21.15 grams. Rediumsfoun
Radium found, 3.00, 3.28, and 3.18, average 3.15 micrograms.
It seems to me that in computing the rate of excretion we should
use the quantity of radium found in the pig killed after 15
minutes after the injection rather than the theoretical quantity
of 5 micrograms in the ampoule.
H. H. Barker.
Physical Laboratory,
December 18, 1925.
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"ocrText": "December 18, 1925.\nDr. F. B. Flinn,\n437 West 59th Street,\nColumbia University,\nNew York City.\nDear Dr. Flinn:-\nI am herewith sending you a copy of the report of the tests made\non Mrs Mallifer's bone. The final values are much higher than\nmy first estimate, which evidently were wrong someplace. On\nthis basis Martland's estimate was not so far wrong.\nI am also enclosing report on the three guinea pigs so far\nreceived.\nWith the Beasons \"reetings, I am,\nYours truly,\nH. H. Barker.\nExperiemtns on the Determination of the Rate of\nExcretion of Radium Solutions Intravenously\ninto Guines Pigs.\nStandard 5 microgram ampoules as put up by the U. S. Radium\nCorporation were used for the injections.\nExperiment 1. 15 minutes after bue injection had been made the\none of the D1gs was killed and incinerated, weight of ash, 24.81 &\nRadium found--- 4.19, and 4.23, average 4.21 micrograms.\nExperiment 2. 24 hours after the injection one p1g was killed\nand incinerated, weight of ash, 21.39 grams.\nRadium found, 3.7, 3.7, and 3.8, average, 3.73 micrograms.\nExperiment 3. 48 hours after the injection one pis was killed\nand incinerated, weight of ash, 21.15 grams. Rediumsfoun\nRadium found, 3.00, 3.28, and 3.18, average 3.15 micrograms.\nIt seems to me that in computing the rate of excretion we should\nuse the quantity of radium found in the pig killed after 15\nminutes after the injection rather than the theoretical quantity\nof 5 micrograms in the ampoule.\nH.H. Barker.\nPhysical Laboratory,\nDecember 18, 1925.\nSample of Bone Cortex and Marrow Taken from\nThe Femurs of Mrs Mallifer.\nThese samples were handed to Mr. Viedt and\nmyself by Dr. Martland shortly after\nNovember 1, 1925.\nThe al gauna rayactivity was measured on a sample containing\nweighing 60.2 grans and expressed in terms of radium equivalent.\nThe actual radium present was determined by the emanation method.\nGamma ray measurements O1 the tube containing 60.2 grams.\n11/13\n0018 mg.\n12/4\n0010\n11/16\n0021\n12/9\n0011\n11/18\n0014 \"\n12/14\n.0020\n11/20\n0015 #\n12/16\n0014\naverage of .0015 mg. or 2.5 X 10-5 mg per gram.\nAssuming the total weight of the bone in the body to be 13/16\nof that in Leman's body (9800 grams) and that this sample 1s\nrepres entative of the total, we calculate the total quantity\nof radium equivalent contained in the body to be 199 micrograms.\nThe smanation values determined were as follows:-\n7.45 X 10⁻⁶ mg. per gram.\n7.50\nIf\n\"\n\"\n11\n7.58\n#\n11\n11\nit\n7.61\n\"\n=\n14\n=\n7.60\nIf\n11\n=\n10\n7.55\n11\n#\n\"\na\naverage.\n13/16 X 9800 X 7.55 X 10-6 gives 60 micragrams of radium element\nIt thus appears that about 30 percent of the total activity can\nbe ascribed to radium while the balance or 70 percent must be\nascribed to mesothorium or radiothorium.\nH. 8. Barker.\nPhysical Laboratory,\nU. S. Radium Corporation,\nDecember 18, 1925.\nExperiemtns on the Determination of the Rate of\nExcretion of Radium Solutions Intravenously\ninto Guines Pigs.\nStandard 5 microgram ampoules as put up by the U. S. Radium\nCorporation were used for the injections.\nExperiment 1. 15 minutes after the injection had been made the\none of the pigs was killed and incinerated, weight of ash, 24.81 &\nRadium found. 4.19, and 4.23, average 4.21 micrograms.\nExperiment 2. 24 hours after the injection one pig was killed\nand incinerated, weight of ash, 21.39 grams.\nRadium found, 3.7, 3.7, and 3.8, average, 3.73 micrograms.\nExperiment 3. 48 hours after the injection one pig was killed\nand incinerated, weight of ash, 21.15 grams. Rediumsfoun\nRadium found, 3.00, 3.28, and 3.18, average 3.15 micrograms.\nIt seems to me that in computing the rate of excretion we should\nuse the quantity of radium found in the pig killed after 15\nminutes after the injection rather than the theoretical quantity\nof 5 micrograms in the ampoule.\nH. H. Barker.\nPhysical Laboratory,\nDecember 18, 1925."
}