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I8.
Clark and hia associates in discussiag tubes for insertion imto maligmant growths are
emphatic in their statenents as to thet effect of bata rays when glass tubes are used.
I glass walls of the tubes are not thick grough to filter out sufficient of the bota
rays, hence there ia frequently as intense sloughing, great pain and heavy fribposis,
leading is
which onta off all circulation to the parts DE to oftem result in further mecrosis.
The prolonged action of the emanations in buriede tubes appear to have a particularly
devitalizing effect on bones. With the metal meedles the irritating beta rays are fil-
tered out and bone necrosia has been observed to be much less frequent with metal
*codles.
Umfortunately almost all of the made n. to the efect of rad ium
and its allied substances are concerned with relatively large amount of material, and
may of them on extermal exposures. Even the experiments in which Mella speaka of mimute
doses he refers to .05 mg for a rabbit weighing approximately 1000 grama which mesna in
proportion .35 mg for the 70 kilo man.
the
Outside of the cases in Orange Pant we do not have any avidence that would ix-
dicate what a daily exposure to infinteaimal amounts of radio notiva material will db
to the organium. Futhhermore these cases are by no mesas cleax eut and one should be ver
careful
in
stating
that
they
are
the
result
of
any
radium
thorium
exposure.
Othor
factor
have not been ruled out and bacteria infection has not been disposed of in a antiafacto
tory mamner. Long continued and carefully controlled experiments will be the oxly way
that thia important question cax be settled.
The theory that the pathological comdition ia the result of the presence of meso-
thorium instead of radium iw not upheld by our examination of the girls. Mella hma ix-
dicated in his work that thorium X does react on different tissues than radium, but his
ia the only observations that we have had and his results lack umiformity. His summery
is that meither im the acute or chromic poisoming of the animal by thorium X can its
organs.
death be traced to changes in the blood forming animala; That there ia a directly op-
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"ocrText": "I8.\nClark and hia associates in discussiag tubes for insertion imto maligmant growths are\nemphatic in their statenents as to thet effect of bata rays when glass tubes are used.\nI glass walls of the tubes are not thick grough to filter out sufficient of the bota\nrays, hence there ia frequently as intense sloughing, great pain and heavy fribposis,\nleading is\nwhich onta off all circulation to the parts DE to oftem result in further mecrosis.\nThe prolonged action of the emanations in buriede tubes appear to have a particularly\ndevitalizing effect on bones. With the metal meedles the irritating beta rays are fil-\ntered out and bone necrosia has been observed to be much less frequent with metal\n*codles.\nUmfortunately almost all of the made n. to the efect of rad ium\nand its allied substances are concerned with relatively large amount of material, and\nmay of them on extermal exposures. Even the experiments in which Mella speaka of mimute\ndoses he refers to .05 mg for a rabbit weighing approximately 1000 grama which mesna in\nproportion .35 mg for the 70 kilo man.\nthe\nOutside of the cases in Orange Pant we do not have any avidence that would ix-\ndicate what a daily exposure to infinteaimal amounts of radio notiva material will db\nto the organium. Futhhermore these cases are by no mesas cleax eut and one should be ver\ncareful\nin\nstating\nthat\nthey\nare\nthe\nresult\nof\nany\nradium\nthorium\nexposure.\nOthor\nfactor\nhave not been ruled out and bacteria infection has not been disposed of in a antiafacto\ntory mamner. Long continued and carefully controlled experiments will be the oxly way\nthat thia important question cax be settled.\nThe theory that the pathological comdition ia the result of the presence of meso-\nthorium instead of radium iw not upheld by our examination of the girls. Mella hma ix-\ndicated in his work that thorium X does react on different tissues than radium, but his\nia the only observations that we have had and his results lack umiformity. His summery\nis that meither im the acute or chromic poisoming of the animal by thorium X can its\norgans.\ndeath be traced to changes in the blood forming animala; That there ia a directly op-"
}