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litter imal quanitty as to make it seem highly impossible to cause the irritation nocessary to end in mecrósis. Another theory that has been advanced is that the particle of radio- active substance may get into the bone through the open spaces in the cancellous struc- ture connected with pyorrhea. The X-Ray has shown open cancellous spaces connected with pyorrhea. It might be possible that during an almost daily expesure thant some ab- sorption of radio-active particles did take place just as pus or infectious germs are absorbed in these pyorrheal open spaces. Statistically this does not seet probable as otherwise we would expect to find other cases reported among the thousands of girls who had the name general habit of pointing their brushes. The dentists who have treated the girls employed at the Orange P1 ,ant admit that pyorrhem existed in almost all of the cases. We studied the irritating effect of the luminous paint on guinea pigs and humans. The sides of a number of piga were shaven and painted daily with the luminous paint for two weeks. We could not detect the reddening of the skin either during the time that the paint wes being applied or at any time after the exposure had ceased. Three of ua in the laboratory painted an area on our arms with the paint end permitted it to re- main on the skin for twenty-four hours. No erythema develop at any time after the re- moval of the paint though the observation was continued over two weeks. The gume of a number of guinea piga and several goats were painted daily for a period of six months, but d uring that time any redness of the gum. One of the goats lost two teeth at differe ent times and we took pains to rub the paint into the gum until the now tooth orme through. Our observations were negative. Unfortunately this goat broke its leg and vas to killed and cremated during our absence thus preventing us from examining the jaw bone. An X-Ray pieture taken previous tp the accident gave a negative reading. One of course manked could not expect to find any bone change in six monthe and s. series of animals showld A be studied over a period of years. This is especially true if intravenous injections of radio-active material is to contimue. In" radium thorium sulphate is a hu ndrede times less soluble than barium

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    "ocrText": "litter\nimal quanitty as to make it seem highly impossible to cause the irritation nocessary\nto end in mecrósis. Another theory that has been advanced is that the particle of radio-\nactive substance may get into the bone through the open spaces in the cancellous struc-\nture connected with pyorrhea. The X-Ray has shown open cancellous spaces connected\nwith pyorrhea. It might be possible that during an almost daily expesure thant some ab-\nsorption of radio-active particles did take place just as pus or infectious germs are\nabsorbed in these pyorrheal open spaces. Statistically this does not seet probable as\notherwise we would expect to find other cases reported among the thousands of girls\nwho had the name general habit of pointing their brushes. The dentists who have treated\nthe girls employed at the Orange P1 ,ant admit that pyorrhem existed in almost all of the\ncases.\nWe studied the irritating effect of the luminous paint on guinea pigs and humans.\nThe sides of a number of piga were shaven and painted daily with the luminous paint\nfor\ntwo\nweeks.\nWe\ncould\nnot\ndetect\nthe\nreddening\nof\nthe\nskin\neither\nduring\nthe\ntime\nthat\nthe paint wes being applied or at any time after the exposure had ceased. Three of ua\nin the laboratory painted an area on our arms with the paint end permitted it to re-\nmain on the skin for twenty-four hours. No erythema develop at any time after the re-\nmoval of the paint though the observation was continued over two weeks. The gume of a\nnumber of guinea piga and several goats were painted daily for a period of six months,\nbut d uring that time any redness of the gum. One of the goats lost two teeth at differe\nent times and we took pains to rub the paint into the gum until the now tooth orme\nthrough. Our observations were negative. Unfortunately this goat broke its leg and vas to\nkilled and cremated during our absence thus preventing us from examining the jaw bone.\nAn X-Ray pieture taken previous tp the accident gave a negative reading. One of course\nmanked\ncould not expect to find any bone change in six monthe and s. series of animals showld\nA\nbe studied over a period of years. This is especially true if intravenous injections\nof radio-active material is to contimue.\nIn\" radium thorium sulphate is a hu ndrede times less soluble than barium"
}