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February lst,1930. Dr. Harry H. Bowing, c/o Mayo Clinic, Rochester, Minn. Dear Dr. Bowing: I am glad to herewith confirm in letter form the matter dis- cussed with you personally on Monday January 27th. From 1916 to 1925 the United States Radium Corporation or its predecessors maintained an application plant for applying radioactive luminous material to watch, clock dials, etc., during which period there were probably employed a total of approximately 400 girls. The radioactive luminous material was applied to the numerals of the dials with small camel's hair brushes. As you realize, this operation is rather a delicate one and requires consider- able skill. The brushes had to be well "pointed" and to do this a good many of the operators used their lips, although there were other methods provided. While the practice of "pointing" the brushes with their lips was forbidden on account of sanitary reasons, still the girls continued the practice with our knowledge. Early in 1924 a dentist in Newark called to our attention the fact that he felt there was an industrial hazard existing in our work. We imediately had a study made, with reference to the materials used as well as working conditions, by the Public Health Department of Harvard. Due to the fact that they could not attribute a similar condition which they found exist- ing in a number of our employees to any particular cause, they advised us that they would look upon the radioactive constituents of our material with suspicion, and advised certain recommendations which we immediately put into effect. We followed this up by discussing the possibilities of the radium presenting B hazard, with both medical and scientific men versed in the subject of radio- activity, and they both felt that the conclusions drawn by the Public Health School of Harvard were rather far fetched. We had other investigations made some of which indicated that it was questionable whether there was an industrial hazard existing in our plant. However, as time progressed and more data and information became available regarding the conditions existing among certain of our employees who had been engaged in this practice, our attitude changed and we recognized that there probably was a hazard connected with this work. The seat of the trouble could be traced back to the practice of "pointing" the brushes with the lips, thereby serving as a means of introducing the material into the system. The radioactive luminous material consisted of phosphorescent zincalphide, which is primarily sine sulphide of a special crystaline nature, containing one (1) part of cadmium sulphide to 820 parts of zine sulphide, one (1) part of copper sulphide to 7150 parts of zinc sulphide, and one (1) part of manganous sulphide to 23000 parts of zinc sulphide. The radium or mosothorium was do -2- was added to the basic zinc sulphide mechanically, and the amount varied from one (1) part in 140,000 to one (1) part in 33,000. Inasmuch as it was not a loaded brush which was "pointed", but the dry brush, it is obvious that at the worst the amount of radio-active zine sulphide that could be ingested per day would be very small. However, as small as this amount must have been we have found a few cases where the system has absorbed some of the radioactive constituents and it has been deposited thruout the bony skeleton. The deposit of this material has persisted after a period of several years, and it is now the theory that the continued action of the alpha particles from the radioactive materials so deposited has been the cause of many of the conditions reported among these employees. In 1925, two cases that were diagnosed as suffering from the result of their employment by us brought suit suit for damages, and were settled. In June, 1928, there was a group of five cases, which had been given wide publicity, thru their efforts in endeavoring to obtain redress, by the press, these were also settled. These cases you probably are more or less familier with thru such publicity, and the information which I gave you. We are now confronted with building a defense in four (4) more cases that have been instituted against us. In this connection they charge us with contributory negligence, in that TTO did not provide proper precautions for these employees during the periods of their employment from 1916 to 1924. They claim that it was common knowledge at that time that even small amounts of radioactive materials taken into the system was deleterious, and that to was well known, and that we should have been aware of it. On the contrary we maintain that there was no reason why we should have been suspicious that even though very minute amounts had been ingested that there was any possibility of hasard arising from the practice. This conclusion was based primarily upon the fact that during this time radium chloride was administered internally for certain conditions under medical supervision, and that there had never been reported in the literature any untoward effects resulting from this practice. We further maintain that even though we had been aware that small amounts of luminous zinc sulphide were being ingested daily we should not have viewed this with any particular alarm, due to the fact that the radium or mesothorium, as the case might have been, was percipitated upon the sufface of the zinc sulphide in an insoluble form - that is the sulphate, and knowing that radium sulphate is one of the most insoluble inorganic compounds known we should have felt a certain amount of confidence that the material would of necessity pass thru the alimintary tract without any appreciable amount being absorbed. It is in this connection that we are endeavoring to enlist the aid of men in the medical profession whose standing is unquestionable, and who have had experience in this type of medication. As you know the number of men qualified in this particular line is very limited, and we are, therefore, appealing to you to assist us by allowing us to take your deposition to the effect that you either administered directly, or that under your supervision radium chloride was administered for the relief of certain pathalogical con- ditions. Also that you were in the main familiar with the literature upon the subject, and that as far as you knew there had never been an untoward effect reported, and that in your experience you know of no untoward effects with the use of this type of medication. We propose to thereby establish that up until 1925, we may say that the use of radium chloride internally -3- in moderation was never considered befraught with any hazards I am confident that you will give this matter your careful considera- tion, and that you will give us your assistance by allowing us to establish these facts from the experience you have had in this line. I trust that when you discuss this matter with your Board of Governors of the Mayo Clinic they will appreciate the situation with which we are con- fronted and consent to your serving in the capacity we have discussed. You are fully aware of what we are confronted with, in that any or every girl who ever has a pain or an ache of any nature will be inclined to ascribe it to the effects of exposure to redium during her employment by us. While we recognize that there are certain cases existing, still we also have knowledge to the effect that a goodly number of the girls have never been effected. Sincerely yours, Vice President. HHBarker: RH

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    "ocrText": "February lst,1930.\nDr. Harry H. Bowing,\nc/o Mayo Clinic,\nRochester, Minn.\nDear Dr. Bowing:\nI am glad to herewith confirm in letter form the matter dis-\ncussed with you personally on Monday January 27th.\nFrom 1916 to 1925 the United States Radium Corporation or its\npredecessors maintained an application plant for applying radioactive luminous\nmaterial to watch, clock dials, etc., during which period there were probably\nemployed a total of approximately 400 girls. The radioactive luminous material\nwas applied to the numerals of the dials with small camel's hair brushes.\nAs you realize, this operation is rather a delicate one and requires consider-\nable skill. The brushes had to be well \"pointed\" and to do this a good many of\nthe operators used their lips, although there were other methods provided. While\nthe practice of \"pointing\" the brushes with their lips was forbidden on account\nof sanitary reasons, still the girls continued the practice with our knowledge.\nEarly in 1924 a dentist in Newark called to our attention the\nfact that he felt there was an industrial hazard existing in our work. We\nimediately had a study made, with reference to the materials used as well as\nworking conditions, by the Public Health Department of Harvard. Due to the\nfact that they could not attribute a similar condition which they found exist-\ning in a number of our employees to any particular cause, they advised us that\nthey would look upon the radioactive constituents of our material with suspicion,\nand advised certain recommendations which we immediately put into effect. We\nfollowed this up by discussing the possibilities of the radium presenting B\nhazard, with both medical and scientific men versed in the subject of radio-\nactivity, and they both felt that the conclusions drawn by the Public Health\nSchool of Harvard were rather far fetched. We had other investigations made\nsome of which indicated that it was questionable whether there was an industrial\nhazard existing in our plant. However, as time progressed and more data and\ninformation became available regarding the conditions existing among certain\nof our employees who had been engaged in this practice, our attitude changed\nand we recognized that there probably was a hazard connected with this work.\nThe seat of the trouble could be traced back to the practice of \"pointing\" the\nbrushes with the lips, thereby serving as a means of introducing the material\ninto the system.\nThe radioactive luminous material consisted of phosphorescent\nzincalphide, which is primarily sine sulphide of a special crystaline nature,\ncontaining one (1) part of cadmium sulphide to 820 parts of zine sulphide, one\n(1) part of copper sulphide to 7150 parts of zinc sulphide, and one (1) part of\nmanganous sulphide to 23000 parts of zinc sulphide. The radium or mosothorium\nwas do\n-2-\nwas added to the basic zinc sulphide mechanically, and the amount varied from\none (1) part in 140,000 to one (1) part in 33,000.\nInasmuch as it was not a loaded brush which was \"pointed\", but the\ndry brush, it is obvious that at the worst the amount of radio-active zine\nsulphide that could be ingested per day would be very small. However, as\nsmall as this amount must have been we have found a few cases where the system\nhas absorbed some of the radioactive constituents and it has been deposited\nthruout the bony skeleton. The deposit of this material has persisted after\na period of several years, and it is now the theory that the continued action\nof the alpha particles from the radioactive materials so deposited has been the\ncause of many of the conditions reported among these employees.\nIn 1925, two cases that were diagnosed as suffering from the result\nof their employment by us brought suit suit for damages, and were settled.\nIn June, 1928, there was a group of five cases, which had been given wide\npublicity, thru their efforts in endeavoring to obtain redress, by the press,\nthese were also settled. These cases you probably are more or less familier\nwith thru such publicity, and the information which I gave you.\nWe are now confronted with building a defense in four (4) more\ncases that have been instituted against us. In this connection they charge\nus with contributory negligence, in that TTO did not provide proper precautions\nfor these employees during the periods of their employment from 1916 to 1924.\nThey claim that it was common knowledge at that time that even small amounts\nof radioactive materials taken into the system was deleterious, and that to\nwas well known, and that we should have been aware of it.\nOn the contrary\nwe maintain that there was no reason why we should have been suspicious that\neven though very minute amounts had been ingested that there was any possibility\nof hasard arising from the practice. This conclusion was based primarily\nupon the fact that during this time radium chloride was administered internally\nfor certain conditions under medical supervision, and that there had never\nbeen reported in the literature any untoward effects resulting from this\npractice. We further maintain that even though we had been aware that\nsmall amounts of luminous zinc sulphide were being ingested daily we should\nnot have viewed this with any particular alarm, due to the fact that the radium\nor mesothorium, as the case might have been, was percipitated upon the sufface\nof the zinc sulphide in an insoluble form - that is the sulphate, and knowing\nthat radium sulphate is one of the most insoluble inorganic compounds known\nwe should have felt a certain amount of confidence that the material would of\nnecessity pass thru the alimintary tract without any appreciable amount being\nabsorbed.\nIt is in this connection that we are endeavoring to enlist the aid\nof men in the medical profession whose standing is unquestionable, and who\nhave had experience in this type of medication. As you know the number of men\nqualified in this particular line is very limited, and we are, therefore,\nappealing to you to assist us by allowing us to take your deposition to the\neffect that you either administered directly, or that under your supervision\nradium chloride was administered for the relief of certain pathalogical con-\nditions. Also that you were in the main familiar with the literature upon\nthe subject, and that as far as you knew there had never been an untoward\neffect reported, and that in your experience you know of no untoward effects\nwith the use of this type of medication. We propose to thereby establish\nthat up until 1925, we may say that the use of radium chloride internally\n-3-\nin moderation was never considered befraught with any hazards\nI am confident that you will give this matter your careful considera-\ntion, and that you will give us your assistance by allowing us to establish\nthese facts from the experience you have had in this line.\nI trust that when you discuss this matter with your Board of Governors\nof the Mayo Clinic they will appreciate the situation with which we are con-\nfronted and consent to your serving in the capacity we have discussed.\nYou are fully aware of what we are confronted with, in that any or every girl\nwho ever has a pain or an ache of any nature will be inclined to ascribe it\nto the effects of exposure to redium during her employment by us.\nWhile we recognize that there are certain cases existing, still we\nalso have knowledge to the effect that a goodly number of the girls have\nnever been effected.\nSincerely yours,\nVice President.\nHHBarker: RH"
}