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Several writers, one as early as
salts which vere not eliminated from the body would eventually be
deposited in the bone structuro and there replace the calciun and
actually becone a part of the structure in the form of radium sul-
phate.
This was theory and there were no computations at that
time to indicate what percentage of a given amount of the soluble or
insoluble salt taken internally would eventually reach the bone.
There is evidence in the literature that radioactive salts in-
3
troduced in the body would be eliminated in part very alowly.
Assuming that was established it might be a feir inference but suro-
ly not conclusive that radium given in frequent doses was cunulative
in its nature and e ffect.
The evidence shows that in 1917 many dangers to the human body
from radium and radium manation were recognized. Long exposure to
emanation, irradiation, and X-rays had resulted, among a fow tech-
nicians and 6 cientific men, in fatal or dangerous injuries.
4
an
article published in 1914 was entitled "Conoerning Occupational
5
Injuries Due to Radioactive Substances,"
and another, "Occupation=
al Diseases Due to Radium; Report of Cases."8
Those articles wore
principally concerned with external burns of the sicin.
2. Seil, Viol and Gordon, *Elimination or Soluble Radium Salts, Taken
Intravenously and Per Oa", (May 1, 1915) New York Medical Journal p.
896, Exhibit P-34; Dominici and LaBordes, "Study on Injection of
Radium Salts", (1913) Comptes Rendeus Des Seances De L'AGademie Des
Sciences, 156, 1107-1109, Exhibit P-18; and "Concerning Fixation By
the Skeleton of Radium Injected in the Soluble State" (1913), Seances
Et Menoirs De La Societe De Biologie, 75; 108-110, Exhibit P-13.
3. Dominioi and the La Bordes, supra note 2.
4. Mesernitzky, St. Petersburg-reuznooh, *Concerning Injury to the
System Through Large Doses of Radium manation" (1914), publication not
given, ExhibitF-6; "Contribution on the Biological and Pathological
Action of Boluble Radium Salts - With Special Reference to its Thern-
peutic Value in Pernicious Anacmia and Leukemia", (1914), "Radium"
Vol.III, No. 5, p. 65, Exhibit P-21a; Part II of name article, Vol.III,
No.6, p. 85, Exhibit p-21B; Rolleston, "The Harmful Effects of Irradi-
ation", (1930), The quarterly Journal or Medicine, No. 93, p. 101,
Exhibit P-49.
5. Outzendt and Halberstaedter - Duetsche-Medizinisohe Wochenschrift,
March 26, 1914, p. 633, Exhibit P-9.
6. Ordway, The Journal of American Medical Association, Vol. LXVI,
No.l, p. 1, 916,-Exhibit P-26.
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"ocrText": "Several writers, one as early as\nsalts which vere not eliminated from the body would eventually be\ndeposited in the bone structuro and there replace the calciun and\nactually becone a part of the structure in the form of radium sul-\nphate.\nThis was theory and there were no computations at that\ntime to indicate what percentage of a given amount of the soluble or\ninsoluble salt taken internally would eventually reach the bone.\nThere is evidence in the literature that radioactive salts in-\n3\ntroduced in the body would be eliminated in part very alowly.\nAssuming that was established it might be a feir inference but suro-\nly not conclusive that radium given in frequent doses was cunulative\nin its nature and e ffect.\nThe evidence shows that in 1917 many dangers to the human body\nfrom radium and radium manation were recognized. Long exposure to\nemanation, irradiation, and X-rays had resulted, among a fow tech-\nnicians and 6 cientific men, in fatal or dangerous injuries.\n4\nan\narticle published in 1914 was entitled \"Conoerning Occupational\n5\nInjuries Due to Radioactive Substances,\"\nand another, \"Occupation=\nal Diseases Due to Radium; Report of Cases.\"8\nThose articles wore\nprincipally concerned with external burns of the sicin.\n2. Seil, Viol and Gordon, *Elimination or Soluble Radium Salts, Taken\nIntravenously and Per Oa\", (May 1, 1915) New York Medical Journal p.\n896, Exhibit P-34; Dominici and LaBordes, \"Study on Injection of\nRadium Salts\", (1913) Comptes Rendeus Des Seances De L'AGademie Des\nSciences, 156, 1107-1109, Exhibit P-18; and \"Concerning Fixation By\nthe Skeleton of Radium Injected in the Soluble State\" (1913), Seances\nEt Menoirs De La Societe De Biologie, 75; 108-110, Exhibit P-13.\n3. Dominioi and the La Bordes, supra note 2.\n4. Mesernitzky, St. Petersburg-reuznooh, *Concerning Injury to the\nSystem Through Large Doses of Radium manation\" (1914), publication not\ngiven, ExhibitF-6; \"Contribution on the Biological and Pathological\nAction of Boluble Radium Salts - With Special Reference to its Thern-\npeutic Value in Pernicious Anacmia and Leukemia\", (1914), \"Radium\"\nVol.III, No. 5, p. 65, Exhibit P-21a; Part II of name article, Vol.III,\nNo.6, p. 85, Exhibit p-21B; Rolleston, \"The Harmful Effects of Irradi-\nation\", (1930), The quarterly Journal or Medicine, No. 93, p. 101,\nExhibit P-49.\n5. Outzendt and Halberstaedter - Duetsche-Medizinisohe Wochenschrift,\nMarch 26, 1914, p. 633, Exhibit P-9.\n6. Ordway, The Journal of American Medical Association, Vol. LXVI,\nNo.l, p. 1, 916,-Exhibit P-26."
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