Letters Sent to Dr. James Ewing, May 27, 1932

May 27th, 1932. Dr. James Ewing Department of Pathology Cornell University Medical College lst Avenue and 28th Street New York City Dear Dr. Ewing: I have before me a letter from Mr. Barker stat- ing that he has talked to you about our research program on Radium and its Biological Applications. In writing to Mr. Barker I made no attempt to outline the experimentel work which we have under way and for the expansion of which we are seeking support from the Josiah Macey Junior Foundation. It is gratifying to us to hear that you stand ready to help us in making our appeal. We hope that the following outline of experimental work in progress hore at the University of Mis- souri will offer cunvincing evidence that our program morits your full endorsement. 1. The experimentol Thork on the Detection and Elimination of Radium in Living Persons, published in the Journal of Reentgenology and Radium Tharapy is being continued. In cooperation with your Commission, Dr. Craver and I have conducted a series of, experiments on four of the girls having radium poisoning to asportain whether the rate of elimination of radium can be greatly increased by the administration of parathormone and viosterol as reported by Flinn and Seidlin. While these investigators report an apparent elimination of radium of 50 per cent, our experiments resulted in showing practically no increase in the rate of elimination. These re- sults will be ready for publication as soon as we can complete a final series of neasurements on the radium still retained by the subjects under experiment. To grin further knowledge on the retention and elimination of radium we have this year conducted experiments on animals. Two graduate students, Horace Thomas and Frank Bruner, working jointly with Dean Allen of the Medical School and myself, have extended the scope of the experiment by a study of the histologioal and pathological effects produced when radium is administered to rats. Under separate cover we are mailing you a copy of the report on this work organized in the form of a thesis subnitted for the degree of Master of Arts, under the title, Chronic Radium Poisoning in Rats. To carry forward this promising line of investi- gation we propose to extend experiments of this kind to larger