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24.
In case that you state they are eliminated, do you have any idea how rapidly such
elimination occurs.
25.
Are you familiar with the work of Siol, Viol end Gordon, done in 1915, with
reference to the rate of elimination of radium chloride administered internally.
26.
Is it not true that within 5 days after an injection of radium chloride internally
or intramuscularli 35 to 45% is eliminated by way of the feces and urine, and
in
that radium chloride given by mouth 65 to 75% is eliminated at the expiration of
5 days.
)
fail 1
15
Is it not true that those authors further state that after the expiration of the
33
10th day the rate of elimination, regardless of whether the radium chlorido used
was given intravenously, intramuscularly or per os, is practically the same and
that it is slightly less than 1%
Based upon this work how long a period of time would you assume would be required
by a patient, who had an injection of say 50 micrograms of radium element, before
would int it would and be practically the prounticlly all all eliminated. eliminated in sittal month to inght to m months years
29.
Are you familiar with the work of Dominiciend his associates, published in the
literature around 1910 to 13, with reference to the internal administration of
rad inm sults.
30.
Is it not a fact that Dominicie was directing his efforts towards developing a
radium preparation which when once introduced into the system would remain for
allonger period of time than the common ordinary soluble salts such as the
chloride
31.
Is it not also true that Domincie did not meet with much success in fixation
of rad um even when the colloidal radium sulphate was administered internally.
32.
Did he not find that this material was eliminated with about the same expediency
as the more suluble salts.
33.
I assume Doctor that you are versed in the solubility of the various products of
raduim, such as the chloride, bromide and sulphate
31.
And that you are aware that the chloride and bromide salts are readily soluble
in aqua solutions, and that the sulphate of radium is considered one of the most
insoluble inorganic compounds on which we have information
33.
I further assume that you are aware that radium, and the more common element
barium are/analogous in their chemical behaviour, and that even though barium
sulphate is considered practically insoluble, that radim sulphate is 100 times
less soluble or has a solubility approximately 1/100 of barium sulphate. Based
upon these facts let us outline two cases: First - that a definite amount of
a
soluble salt, such as radium chloride be taken by mouth, and second, that a like
amount in the form of the sulphate be taken by mouth, what would be your assumption
as to the course of the radium in these two instances.
36.
Would you not assume in view of the highly insoluble nature of radium sulphate
that it would practically all be eliminated thru the feces, and that a certain
amount of the soluble salt would in all probability be picked up by the blood
stream.
You
under stand the This question is purely a hypothical one, and
one which we ask for your opinion based upon the knowledge of the art as of
1915 and 1925, or any period between these dates, and not in view of the informa-
tion which we have at the present time.
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"ocrText": "24.\nIn case that you state they are eliminated, do you have any idea how rapidly such\nelimination occurs.\n25.\nAre you familiar with the work of Siol, Viol end Gordon, done in 1915, with\nreference to the rate of elimination of radium chloride administered internally.\n26.\nIs it not true that within 5 days after an injection of radium chloride internally\nor intramuscularli 35 to 45% is eliminated by way of the feces and urine, and\nin\nthat radium chloride given by mouth 65 to 75% is eliminated at the expiration of\n5 days.\n)\nfail 1\n15\nIs it not true that those authors further state that after the expiration of the\n33\n10th day the rate of elimination, regardless of whether the radium chlorido used\nwas given intravenously, intramuscularly or per os, is practically the same and\nthat it is slightly less than 1%\nBased upon this work how long a period of time would you assume would be required\nby a patient, who had an injection of say 50 micrograms of radium element, before\nwould int it would and be practically the prounticlly all all eliminated. eliminated in sittal month to inght to m months years\n29.\nAre you familiar with the work of Dominiciend his associates, published in the\nliterature around 1910 to 13, with reference to the internal administration of\nrad inm sults.\n30.\nIs it not a fact that Dominicie was directing his efforts towards developing a\nradium preparation which when once introduced into the system would remain for\nallonger period of time than the common ordinary soluble salts such as the\nchloride\n31.\nIs it not also true that Domincie did not meet with much success in fixation\nof rad um even when the colloidal radium sulphate was administered internally.\n32.\nDid he not find that this material was eliminated with about the same expediency\nas the more suluble salts.\n33.\nI assume Doctor that you are versed in the solubility of the various products of\nraduim, such as the chloride, bromide and sulphate\n31.\nAnd that you are aware that the chloride and bromide salts are readily soluble\nin aqua solutions, and that the sulphate of radium is considered one of the most\ninsoluble inorganic compounds on which we have information\n33.\nI further assume that you are aware that radium, and the more common element\nbarium are/analogous in their chemical behaviour, and that even though barium\nsulphate is considered practically insoluble, that radim sulphate is 100 times\nless soluble or has a solubility approximately 1/100 of barium sulphate. Based\nupon these facts let us outline two cases: First - that a definite amount of\na\nsoluble salt, such as radium chloride be taken by mouth, and second, that a like\namount in the form of the sulphate be taken by mouth, what would be your assumption\nas to the course of the radium in these two instances.\n36.\nWould you not assume in view of the highly insoluble nature of radium sulphate\nthat it would practically all be eliminated thru the feces, and that a certain\namount of the soluble salt would in all probability be picked up by the blood\nstream.\nYou\nunder stand the This question is purely a hypothical one, and\none which we ask for your opinion based upon the knowledge of the art as of\n1915 and 1925, or any period between these dates, and not in view of the informa-\ntion which we have at the present time."
}