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Drinker folder REPORT or AN INVESTIGATION OF THE CAUSE OF NECROSIS OF THE JAW OCOURRING IN CERTAIN TORKERS EMPLOYED BY OR TOMIERLY IN THE RUPLOY OF THE UNITED STATES RADIUI CORPORATION. This investigation tas bogun following the receipt of a letter from Itr. Rodder, dated 12,1924, giving en account of ter cases of necrosie of the jom occurting in employees of the United States Radium Corporation - one fatal case and one existing case, supposedly on the mend. Careful inquiries and investigations made during two visits to the plant in Orange hatre enabled us to trace the following instances of chronic disesse processes occurring in the Jaw bones or employees in the application of luminous paint. Case 1. - 11. Maggia, employed from October 1,1917, to January 25th,1922, developed a necrosie of the jom and later died. Cage 11. - Mães Virginia Fudolph, employed from Septenber 23,1918, to April 13,1921, devoloped, following the extraction of a tnoth by Dr. W.T.Barry of Herrark, a rapidly progressing necrosic of the jan, not Improved by curetting eight or nine times. lies Trudolph finally died as a result of this disense process. Case 111. - Viss Vincent (Now lirs. Ruser) employed from 1917 to 1920 inclusive, developed, following the extraction of a tooth five months ago, progressive necrosis of the necessitsting the removel of mach of her left uppor Jan and tro blood transfusions. Dr. Theodore the dertal surgeon in charge of this reports that a necrotic process has now begun in the right side of the lorrer jam and that the pationt is in a very serious condition. Case lv. - Mies Margarot Carlough, employed, by her own and hor sister's account, for a period of six and ono-half years ending last December, beran to fail in health three years ago. Hor symptoms were extreme Intigue and weskess with pallor. She continued Hor work in spite of increasing 11 honlth and in October,1924, developed a toothache with local swolling of the face. On December 24,1923, she had en upper and lower richt molar pulled, a piece of decayed bone coming out with one of these teeth. She then stopped work. Normal henling of the Jam did not ensue; instend, a discharge of pus began and persisted. Later two other teeth at somo distance beceme affectod and were extracted. She has, at present, in addition to the in the lower Jaw, a new sinus in the upper jaw communicatini with the antrom, as shown by X-rays. Her appearance is very bad. She has lost mach weight and ie very pale. ller blood, on microscopical emmination, shors a profound anemis. Sho complains of pain in the bones of her fnee, has considerable inconvenience from the discharge of foul pus in Her mouth and is forced to spend much of her time in bed. She says, however, that lately the has folt a little better - a statement not in accord with her appearance and with the now septic process. We believe this girl to be in an extremely serious condition. The accompanying X-rays show the condition of Mãss Carlown's Jem on May 7,1924. These films show necrosie of the right upper maxilla with a gront deal of clouding of the antrum and un apparent tendency to extend into the nose. The necrosis is not yot great enoudh to cause loss of all the teeth, but the condition of the antruo and the tendency of the process to extend upwards toward the sicull mokes one Na possible onnet of menin/itis.